INT257685

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Context Info
Confidence 0.61
First Reported 2008
Last Reported 2008
Negated 2
Speculated 2
Reported most in Body
Documents 1
Total Number 11
Disease Relevance 2.86
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gja3) plasma membrane (Gja3)
Anatomy Link Frequency
myocytes 4
heart 4
Gja3 (Mus musculus)
Pain Link Frequency Relevance Heat
Action potential 110 97.20 Very High Very High Very High
ischemia 11 96.68 Very High Very High Very High
action potential duration 220 96.04 Very High Very High Very High
potassium channel 22 5.00 Very Low Very Low Very Low
sodium channel 22 5.00 Very Low Very Low Very Low
anesthesia 11 5.00 Very Low Very Low Very Low
isoflurane 11 5.00 Very Low Very Low Very Low
Calcium channel 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Heart Disease 33 99.84 Very High Very High Very High
Dilated Cardiomyopathy 11 99.24 Very High Very High Very High
Cv Unclassified Under Development 22 99.00 Very High Very High Very High
Infarction 11 97.16 Very High Very High Very High
Malignant Neoplastic Disease 11 88.00 High High
Heart Rate Under Development 11 87.92 High High
Targeted Disruption 55 84.24 Quite High
Sprains And Strains 11 83.84 Quite High
Myocardial Infarction 11 79.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have recently shown that short-term pacing in the mouse is associated with changes in connexin43 (Cx43) expression and localization but not with increased inducibility into sustained arrhythmias.
Neg (not) Regulation (changes) of Gene_expression (expression) of Cx43
1) Confidence 0.61 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Abstract Doc Link PMC2614590 Disease Relevance 0.07 Pain Relevance 0
We recently demonstrated that alterations in Cx43 expression in the wild-type mouse heart could be induced by ventricular pacing over a short period of time.
Regulation (alterations) of Gene_expression (expression) of Cx43 in heart
2) Confidence 0.61 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0.66 Pain Relevance 0.03
hearts did not significantly affect overall Cx43 protein levels (Fig. 2B).
Neg (not) Regulation (affect) of Gene_expression (levels) of Cx43 in hearts
3) Confidence 0.45 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0 Pain Relevance 0.07
We investigated the effect of reduced Cx43 expression on pacing-induced remodeling of repolarizing currents using Cx43+/?
Spec (investigated) Regulation (effect) of Gene_expression (expression) of Cx43
4) Confidence 0.45 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0.08 Pain Relevance 0.15
Thus, in combination with the data presented in this study, it is reasonable to conclude that reduced Cx43 expression, as observed in the infarct border zone and in paced Cx43+/?
Regulation (conclude) of Gene_expression (expression) of Cx43
5) Confidence 0.45 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0.17 Pain Relevance 0
To investigate how pacing in the setting of reduced Cx43 expression influences electrophysiological properties, we used whole-cell patch-clamp techniques to record action potentials in ventricular myocytes obtained from unpaced and paced wild-type and Cx43+/?
Spec (investigate) Regulation (setting) of Gene_expression (expression) of Cx43 in myocytes associated with action potential
6) Confidence 0.45 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0 Pain Relevance 0.23
Myocytes isolated from unpaced Cx43+/?
Regulation (isolated) of Gene_expression (/) of Cx43 in Myocytes
7) Confidence 0.39 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0 Pain Relevance 0.33
To directly test the effect of pacing in the Cx43+/?
Regulation (effect) of Gene_expression (/) of Cx43
8) Confidence 0.39 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0 Pain Relevance 0
Altered expression of Cx43 in cardiac disease is a potentially significant contributor to arrhythmogenicity (19, 33).
Regulation (Altered) of Gene_expression (expression) of Cx43 associated with heart disease
9) Confidence 0.27 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0.64 Pain Relevance 0.05
In the present study, we hypothesized that alterations in Cx43 expression induced by pacing might have more profound effects on ventricular function and electrophysiology in the setting of reduced basal levels of Cx43.
Regulation (alterations) of Gene_expression (expression) of Cx43
10) Confidence 0.27 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0.60 Pain Relevance 0.03
However, pacing-induced changes in Cx43 expression were not accompanied by decreased cardiac function, prolonged refractoriness, or increased inducibility into sustained arrhythmias (22).
Regulation (changes) of Gene_expression (expression) of Cx43 associated with cv unclassified under development
11) Confidence 0.24 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0.64 Pain Relevance 0.03

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