INT257687

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Context Info
Confidence 0.67
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 0.19
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Kcnn4)
Anatomy Link Frequency
myocytes 1
erythrocytes 1
hearts 1
Kcnn4 (Mus musculus)
Pain Link Frequency Relevance Heat
action potential duration 100 99.20 Very High Very High Very High
potassium channel 10 92.64 High High
Action potential 50 90.24 High High
ischemia 5 11.08 Low Low
sodium channel 10 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
isoflurane 5 5.00 Very Low Very Low Very Low
Calcium channel 5 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 10 75.00 Quite High
Targeted Disruption 26 66.84 Quite High
Cv Unclassified Under Development 10 52.24 Quite High
Malignant Neoplastic Disease 5 31.08 Quite Low
Heart Disease 15 16.20 Low Low
Dilated Cardiomyopathy 5 13.64 Low Low
Infarction 5 11.56 Low Low
Sprains And Strains 7 10.00 Low Low
Volume Depletion And Dehydration 11 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Deoxygenation of sickle erythrocytes activates a cation permeability of unknown molecular identity (Psickle), leading to elevated intracellular [Ca2+] ([Ca2+]i) and subsequent activation of KCa 3.1.
Positive_regulation (activation) of KCa 3.1 in erythrocytes
1) Confidence 0.67 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2806905 Disease Relevance 0.07 Pain Relevance 0
myocytes revealed significantly increased IK1 in the Cx43+/?
Positive_regulation (increased) of IK1 in myocytes
2) Confidence 0.33 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0 Pain Relevance 0.08
As our laboratory has previously demonstrated (9), APD was significantly shorter and steady-state and inward rectifier potassium currents (Iss and IK1, respectively) were increased in Cx43+/?
Positive_regulation (increased) of IK1 associated with action potential duration
3) Confidence 0.33 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0.12 Pain Relevance 0.23
Thus increased IK1 in Cx43+/?
Positive_regulation (increased) of IK1
4) Confidence 0.33 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0 Pain Relevance 0.09
IK1 is increased in Cx43+/?
Positive_regulation (increased) of IK1
5) Confidence 0.33 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0 Pain Relevance 0.42
Isolated myocytes from Cx43-deficient murine hearts have shortened APDs compared with those measured in wild-type cells, most likely due to increased Iss and IK1 density.
Positive_regulation (increased) of IK1 in hearts
6) Confidence 0.15 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0 Pain Relevance 0.13

General Comments

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