INT257688

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Context Info
Confidence 0.58
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 1.15
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gja3) plasma membrane (Gja3)
Anatomy Link Frequency
myocardium 1
sinus 1
hearts 1
Gja3 (Mus musculus)
Pain Link Frequency Relevance Heat
action potential duration 140 99.00 Very High Very High Very High
ischemia 7 96.04 Very High Very High Very High
Action potential 70 86.88 High High
potassium channel 14 5.00 Very Low Very Low Very Low
sodium channel 14 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
isoflurane 7 5.00 Very Low Very Low Very Low
Calcium channel 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 35 99.20 Very High Very High Very High
Heart Disease 21 97.08 Very High Very High Very High
Cv Unclassified Under Development 14 96.04 Very High Very High Very High
Infarction 7 95.64 Very High Very High Very High
Dilated Cardiomyopathy 7 94.04 High High
Malignant Neoplastic Disease 7 67.80 Quite High
Sprains And Strains 7 5.00 Very Low Very Low Very Low
Heart Rate Under Development 7 5.00 Very Low Very Low Very Low
Myocardial Infarction 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
downregulation of connexin43 (Cx43), the major cardiac gap junction protein subtype, has been described in cardiac disease including ischemia, infarction, hibernating myocardium, and dilated cardiomyopathy (20, 21, 24, 30).
Negative_regulation (downregulation) of Cx43 in myocardium associated with heart disease, ischemia, dilated cardiomyopathy and infarction
1) Confidence 0.58 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0.58 Pain Relevance 0.05
In the present study, we hypothesized that alterations in Cx43 expression induced by pacing might have more profound effects on ventricular function and electrophysiology in the setting of reduced basal levels of Cx43.
Negative_regulation (reduced) of Cx43
2) Confidence 0.43 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0.42 Pain Relevance 0.03
In this paper, we describe an interaction between reduced basal levels of Cx43 and pacing that influences ventricular electrophysiology.
Negative_regulation (reduced) of Cx43
3) Confidence 0.43 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0 Pain Relevance 0.11
hearts had significantly reduced Cx43 protein levels compared with matched samples from littermate wild-types (34.3 ± 4.4% of wild-type Cx43 levels; P < 0.01; Fig. 2A).
Negative_regulation (reduced) of Cx43 in hearts
4) Confidence 0.43 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0 Pain Relevance 0.03
Pacing in the setting of heterozygous loss of Cx43, but not in wild-type mice, is associated with prolonged refractoriness.
Negative_regulation (loss) of Cx43
5) Confidence 0.43 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0 Pain Relevance 0.12
APD is significantly lengthened with a corresponding reduction in Iss (but not IK1) in paced Cx43+/?
Negative_regulation (reduction) of Cx43 associated with action potential duration
6) Confidence 0.37 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0.06 Pain Relevance 0.13
 ; 66% mean reduction in Cx43) mice for 6 h at 10–15% above their average sinus rate.
Negative_regulation (reduction) of Cx43 in sinus
7) Confidence 0.37 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Abstract Doc Link PMC2614590 Disease Relevance 0.10 Pain Relevance 0.04

General Comments

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