INT25771

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Context Info
Confidence 0.10
First Reported 1989
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 3.67
Pain Relevance 1.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (DSP) structural molecule activity (DSP) plasma membrane (DSP)
protein binding, bridging (DSP) cytoplasm (DSP)
Anatomy Link Frequency
thymus 1
ankle 1
T lymphocytes 1
DSP (Homo sapiens)
Pain Link Frequency Relevance Heat
opiate 6 100.00 Very High Very High Very High
narcan 4 100.00 Very High Very High Very High
dexamethasone 4 97.04 Very High Very High Very High
lidocaine 3 94.00 High High
Pain 36 86.72 High High
Peripheral nervous system 4 85.64 High High
Morphine 4 83.28 Quite High
peripheral neuropathy 2 50.00 Quite Low
c fibre 8 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuropathy 116 100.00 Very High Very High Very High
Diabetes Mellitus 185 91.56 High High
Hyperglycemia 8 89.72 High High
Sprains And Strains 7 89.04 High High
Breast Cancer 62 87.84 High High
Pain 36 86.72 High High
Schizophrenia 3 85.40 High High
Cancer 41 84.20 Quite High
Disease 7 78.16 Quite High
Stress 6 74.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One-way ANOVA was used to determine the influence of DSP measures on EMG and ROM data using subgroups defined by severity of neuropathy.
Spec (determine) Regulation (influence) of DSP associated with neuropathy
1) Confidence 0.10 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2940775 Disease Relevance 0.58 Pain Relevance 0
The ‘Polymorphic miRNA’ tables of the Patrocles database can be queried using a variety of filters including species, miRNA (identifier and map position), type of variation (DSP, CNV or eQTL), DSP category (position with respect to miRNA structure, DSP validation status, DSP identifier), CNV identifier and host gene affected by a reported eQTL.


Regulation (affected) of DSP
2) Confidence 0.07 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2808989 Disease Relevance 0.17 Pain Relevance 0
The ‘Polymorphic miRNA’ tables of the Patrocles database can be queried using a variety of filters including species, miRNA (identifier and map position), type of variation (DSP, CNV or eQTL), DSP category (position with respect to miRNA structure, DSP validation status, DSP identifier), CNV identifier and host gene affected by a reported eQTL.


Regulation (affected) of DSP
3) Confidence 0.07 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2808989 Disease Relevance 0.16 Pain Relevance 0
The ‘Polymorphic miRNA’ tables of the Patrocles database can be queried using a variety of filters including species, miRNA (identifier and map position), type of variation (DSP, CNV or eQTL), DSP category (position with respect to miRNA structure, DSP validation status, DSP identifier), CNV identifier and host gene affected by a reported eQTL.


Regulation (affected) of DSP
4) Confidence 0.07 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2808989 Disease Relevance 0.17 Pain Relevance 0
Notably WalBC cells showed up regulated expression of DSP, s100A4, ANXA1, NDRG-1, TK1 and down regulation of genes such as tissue inhibitor of TIMP-3 and TAGLN.
Regulation (regulation) of DSP
5) Confidence 0.06 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2263075 Disease Relevance 0.41 Pain Relevance 0
Multiple types of sensation are affected in DSP including vibration sense [9,10], light touch sensation [6,8], position sense [5,8], temperature discrimination [5,7,8], as well as diminished ankle reflexes [5-8].
Regulation (affected) of DSP in ankle associated with neuropathy
6) Confidence 0.06 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2940775 Disease Relevance 1.72 Pain Relevance 0.13
The aim of the work was to study the effect of glucocorticoids, opiates and stressful stimuli on dipeptidyl peptidase IV (DP IV, EC 3.4.14.5) activity of T lymphocytes prepared from the thymus of intact and adrenalectomized rats.
Regulation (effect) of DP IV in thymus associated with opiate
7) Confidence 0.05 Published 1989 Journal Exp. Clin. Endocrinol. Section Abstract Doc Link 2544437 Disease Relevance 0.23 Pain Relevance 0.50
Changes of dipeptidyl peptidase (DP IV) activity in the T lymphocytes of rats following administration of ACTH, dexamethasone and opiates.
Regulation (Changes) of DP IV in T lymphocytes associated with narcan, opiate and dexamethasone
8) Confidence 0.05 Published 1989 Journal Exp. Clin. Endocrinol. Section Title Doc Link 2544437 Disease Relevance 0.24 Pain Relevance 0.66
Once opened, DPI-modified Na+ channels are highly drug-sensitive.
Regulation (sensitive) of DPI-modified
9) Confidence 0.01 Published 1989 Journal Circ. Res. Section Abstract Doc Link 2539922 Disease Relevance 0 Pain Relevance 0.26

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