INT257727

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Context Info
Confidence 0.72
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 7.38
Pain Relevance 3.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

generation of precursor metabolites and energy (Vgf) extracellular space (Vgf) extracellular region (Vgf)
Anatomy Link Frequency
DRG 2
satellite cells 1
nerve 1
neurons 1
dorsal horn 1
Vgf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn neuron 104 98.64 Very High Very High Very High
Spinal cord 72 95.84 Very High Very High Very High
Neuropathic pain 88 93.32 High High
Peripheral nervous system 8 89.96 High High
Dorsal horn 144 89.12 High High
Hippocampus 24 89.12 High High
Peripheral nerve injury 56 86.76 High High
depression 8 83.00 Quite High
Inflammation 8 73.32 Quite High
central sensitization 8 53.48 Quite High
Disease Link Frequency Relevance Heat
Nervous System Injury 248 99.88 Very High Very High Very High
Neuropathic Pain 136 99.20 Very High Very High Very High
Injury 88 98.80 Very High Very High Very High
Depression 8 83.00 Quite High
INFLAMMATION 8 73.32 Quite High
Nociception 16 67.72 Quite High
Hyperalgesia 8 38.04 Quite Low
Pain 16 37.48 Quite Low
Hypersensitivity 40 31.60 Quite Low
Ganglion Cysts 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pattern of VGF mRNA and protein upregulation in dorsal horn neurons following spared nerve injury
Transcription (Pattern) of VGF in dorsal horn associated with nervous system injury and dorsal horn neuron
1) Confidence 0.72 Published 2008 Journal Mol Pain Section Body Doc Link PMC2614976 Disease Relevance 0.89 Pain Relevance 0.17
VGF is notable for its rapid and strong regulation by NGF and BDNF, which drive vgf gene transcription in vitro and in vivo, increasing VGF mRNA levels up to 50-fold in PC12 cells [13,14].
Transcription (transcription) of vgf
2) Confidence 0.72 Published 2008 Journal Mol Pain Section Body Doc Link PMC2614976 Disease Relevance 0.64 Pain Relevance 0.52
VGF is notable for its rapid and strong regulation by NGF and BDNF, which drive vgf gene transcription in vitro and in vivo, increasing VGF mRNA levels up to 50-fold in PC12 cells [13,14].
Transcription (levels) of VGF
3) Confidence 0.69 Published 2008 Journal Mol Pain Section Body Doc Link PMC2614976 Disease Relevance 0.64 Pain Relevance 0.56
Quantification of the in situ hybridization shows that both the amount of VGF mRNA per cell and the number of cells expressing VGF mRNA is significantly greater in the ipsilateral compared to the contralateral DRG at 7 and 21 days post injury (Figure 1C & D).
Transcription (expressing) of VGF in DRG associated with injury
4) Confidence 0.53 Published 2008 Journal Mol Pain Section Body Doc Link PMC2614976 Disease Relevance 1.07 Pain Relevance 0.37
The number of neurons expressing VGF mRNA increases steadily post injury with a time course that parallels the qPCR data.
Transcription (expressing) of VGF in neurons associated with injury
5) Confidence 0.53 Published 2008 Journal Mol Pain Section Body Doc Link PMC2614976 Disease Relevance 1.05 Pain Relevance 0.45
Pattern of VGF mRNA and protein upregulation in DRG neurons following spared nerve injury
Transcription (Pattern) of VGF in nerve associated with nervous system injury
6) Confidence 0.53 Published 2008 Journal Mol Pain Section Body Doc Link PMC2614976 Disease Relevance 1.00 Pain Relevance 0.61
Quantification of the in situ hybridization shows that both the amount of VGF mRNA per cell and the number of cells expressing VGF mRNA is significantly greater in the ipsilateral compared to the contralateral DRG at 7 and 21 days post injury (Figure 1C & D).
Transcription (amount) of VGF in DRG associated with injury
7) Confidence 0.53 Published 2008 Journal Mol Pain Section Body Doc Link PMC2614976 Disease Relevance 1.03 Pain Relevance 0.38
In situ hybridization (Figure 1B) shows that this upregulation is restricted to DRG neurons; no VGF mRNA expression is observed in glial or satellite cells.
Neg (no) Transcription (expression) of VGF in satellite cells
8) Confidence 0.53 Published 2008 Journal Mol Pain Section Body Doc Link PMC2614976 Disease Relevance 1.06 Pain Relevance 0.47

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