INT257737

Context Info Confidence 0.17 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.07 Pain Relevance 0.35

cytoplasm (HRAS, PTEN) cytosol (HRAS, PTEN) nucleus (HRAS, PTEN) plasma membrane (HRAS, PTEN) Golgi apparatus (HRAS) enzyme binding (PTEN)

HRAS (Homo sapiens) PTEN (Homo sapiens)

Pain Link Frequency Relevance Heat endometriosis 108 99.42 pain pelvic 2 5.00 cytokine 1 5.00 Inflammation 1 5.00 Thalamus 1 5.00 Dismenorea 1 5.00

Disease Link Frequency Relevance Heat Endometriosis 138 99.42 Disease 11 98.92 Ovarian Cancer 15 66.16 Reprotox - General 3 4 5.00 Cancer 3 5.00 Carcinoma 3 5.00 Myelodysplastic Syndromes 2 5.00 Malignant Neoplastic Disease 2 5.00 Reprotox - General 1 1 5.00 Gynecological Disease 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

As overexpression of AXL and SHC1 theoretically activates both PI3K-Akt and MAPK pathways, dysregulation of these genes in human endometriosis may correspond to oncogenic activation of K-ras or biallelic losses of Pten in the mouse model of the disease.

Positive_regulation (activation) of K-ras Negative_regulation (losses) of Pten associated with endometriosis and disease

1) Confidence 0.17 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 1.07 Pain Relevance 0.35

General Comments

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