INT257738

Context Info Confidence 0.16 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.03 Pain Relevance 0.39

cytosol (PIK3CA) signal transduction (PIK3CA) extracellular region (ACTN4) nucleus (ACTN4) protein complex (ACTN4) cytoplasm (ACTN4)

PIK3CA (Homo sapiens) ACTN4 (Homo sapiens)

Pain Link Frequency Relevance Heat endometriosis 108 99.16 pain pelvic 2 5.00 cytokine 1 5.00 Inflammation 1 5.00 Thalamus 1 5.00 Dismenorea 1 5.00

Disease Link Frequency Relevance Heat Endometriosis 138 99.16 Ovarian Cancer 15 95.08 Disease 11 40.00 Endometroid Carcinoma 1 33.32 Cancer 3 24.64 Carcinoma 3 13.60 Reprotox - General 3 4 5.00 Myelodysplastic Syndromes 2 5.00 Malignant Neoplastic Disease 2 5.00 Reprotox - General 1 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

Furthermore, since PI3K can control nuclear translocation of ACTN4, activation of the PI3K-Akt pathway in endometriosis may facilitate enhanced cytoplasmic expression of ACTN4, and may contribute the cell motility and invasion observed in endometriosis.

PI3K Regulation (control) of Localization (translocation) of ACTN4 associated with endometriosis

1) Confidence 0.16 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 1.03 Pain Relevance 0.39

General Comments

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