INT257740

Context Info Confidence 0.07 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.72 Pain Relevance 0.27

cell differentiation (AXL) signal transduction (AXL) nucleolus (SAGE1) plasma membrane (AXL) nucleus (SAGE1)

Anatomy Link Frequency epithelial cells 2 SAGE1 (Homo sapiens) AXL (Homo sapiens)

Pain Link Frequency Relevance Heat endometriosis 108 96.48 pain pelvic 2 5.00 cytokine 1 5.00 Inflammation 1 5.00 Thalamus 1 5.00 Dismenorea 1 5.00

Disease Link Frequency Relevance Heat Endometriosis 138 100.00 Myelodysplastic Syndromes 2 20.08 Ovarian Cancer 15 5.00 Disease 11 5.00 Reprotox - General 3 4 5.00 Cancer 3 5.00 Carcinoma 3 5.00 Malignant Neoplastic Disease 2 5.00 Reprotox - General 1 1 5.00 Gynecological Disease 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

AXL, SHC1, and ACTN4, all shown to be overexpressed in endometriotic epithelial cells by SAGE, were selected for IHC validation.

SAGE Positive_regulation (overexpressed) of Gene_expression (overexpressed) of AXL in epithelial cells associated with endometriosis

1) Confidence 0.07 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 0.72 Pain Relevance 0.27

General Comments

This test has worked.