INT257743

Context Info Confidence 0.21 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.03 Pain Relevance 0.31

cytosol (PIK3CA, SHC1) mitochondrion (SHC1) signal transduction (PIK3CA) aging (SHC1) plasma membrane (SHC1) nucleus (SHC1)

PIK3CA (Homo sapiens) SHC1 (Homo sapiens)

Pain Link Frequency Relevance Heat endometriosis 108 85.60 pain pelvic 2 5.00 cytokine 1 5.00 Inflammation 1 5.00 Thalamus 1 5.00 Dismenorea 1 5.00

Disease Link Frequency Relevance Heat Carcinoma 3 99.60 Endometriosis 138 92.44 Cancer 3 91.04 Endometroid Carcinoma 1 75.36 Ovarian Cancer 15 40.72 Disease 11 5.00 Reprotox - General 3 4 5.00 Myelodysplastic Syndromes 2 5.00 Malignant Neoplastic Disease 2 5.00 Reprotox - General 1 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

SHC1 is an adaptor protein that mediates signal transduction in the MAPK pathway, and that can also interact with the p85 regulatory subunit of PI3K.

PI3K Binding (interact) of SHC1

1) Confidence 0.21 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 1.03 Pain Relevance 0.31

General Comments

This test has worked.