INT257746

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Context Info
Confidence 0.26
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.04
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SHC1, PIK3CA) signal transduction (PIK3CA) mitochondrion (SHC1)
aging (SHC1) plasma membrane (SHC1) nucleus (SHC1)
SHC1 (Homo sapiens)
PIK3CA (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 108 92.80 High High
pain pelvic 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Thalamus 1 5.00 Very Low Very Low Very Low
Dismenorea 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 3 99.12 Very High Very High Very High
Carcinoma 3 93.60 High High
Endometriosis 138 92.80 High High
Endometroid Carcinoma 1 82.56 Quite High
Ovarian Cancer 15 34.72 Quite Low
Disease 11 5.00 Very Low Very Low Very Low
Reprotox - General 3 4 5.00 Very Low Very Low Very Low
Myelodysplastic Syndromes 2 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 2 5.00 Very Low Very Low Very Low
Reprotox - General 1 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SHC1 could therefore contribute the activation of MAPK and/or the activation of the PI3K-Akt pathway in these tumors.
SHC1 Positive_regulation (contribute) of Positive_regulation (activation) of PI3K associated with cancer
1) Confidence 0.26 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 1.04 Pain Relevance 0.34

General Comments

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