INT257750

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.60
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 3.10
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SHC1) mitochondrion (SHC1) aging (SHC1)
plasma membrane (SHC1) nucleus (SHC1) cytoplasm (SHC1)
Anatomy Link Frequency
endometrium 2
SHC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 324 99.68 Very High Very High Very High
pain pelvic 6 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Thalamus 3 5.00 Very Low Very Low Very Low
Dismenorea 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometriosis 414 99.68 Very High Very High Very High
Carcinoma 9 96.96 Very High Very High Very High
Endometroid Carcinoma 3 92.80 High High
Cancer 9 84.12 Quite High
Ovarian Cancer 45 46.72 Quite Low
Disease 33 5.00 Very Low Very Low Very Low
Reprotox - General 3 12 5.00 Very Low Very Low Very Low
Myelodysplastic Syndromes 6 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 6 5.00 Very Low Very Low Very Low
Reprotox - General 1 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The MAPK pathway is therefore constitutively activated in both human endometriosis and in the mouse endometriosis model, and the overexpression of SHC1 is an intriguing mechanism for the activation of this pathway in human endometriosis (Fig. 3).
Positive_regulation (overexpression) of Gene_expression (overexpression) of SHC1 associated with endometriosis
1) Confidence 0.60 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 1.12 Pain Relevance 0.40
Although, the comparison of gene expression profiles between endometriosis and normal endometrium was done for the proliferative phase, AXL, SHC1, and ACTN4 (discussed below) were also overexpressed during secretory phase in ovarian endometriosis.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of SHC1 in endometrium associated with endometriosis
2) Confidence 0.43 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 1.18 Pain Relevance 0.42
The transforming activity of SHC1 has been established [47], and its overexpression has been reported in neoplasias such as breast, gastric and hepatocelullar carcinomas [48-50].
Positive_regulation (overexpression) of Gene_expression (overexpression) of SHC1 associated with carcinoma
3) Confidence 0.43 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 0.81 Pain Relevance 0.21

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox