INT257754

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 4.58
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (ACTN4) nucleus (ACTN4) protein complex (ACTN4)
cytoplasm (ACTN4)
Anatomy Link Frequency
endometrium 2
lung 2
ACTN4 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 432 99.68 Very High Very High Very High
pain pelvic 8 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Thalamus 4 5.00 Very Low Very Low Very Low
Dismenorea 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometriosis 552 99.68 Very High Very High Very High
Ovarian Cancer 60 99.00 Very High Very High Very High
Endometroid Carcinoma 4 82.04 Quite High
Cancer 12 73.36 Quite High
Carcinoma 12 62.32 Quite High
Disease 44 48.72 Quite Low
Reprotox - General 3 16 5.00 Very Low Very Low Very Low
Myelodysplastic Syndromes 8 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 8 5.00 Very Low Very Low Very Low
Reprotox - General 1 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although, the comparison of gene expression profiles between endometriosis and normal endometrium was done for the proliferative phase, AXL, SHC1, and ACTN4 (discussed below) were also overexpressed during secretory phase in ovarian endometriosis.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of ACTN4 in endometrium associated with endometriosis
1) Confidence 0.45 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 1.17 Pain Relevance 0.42
Furthermore, since PI3K can control nuclear translocation of ACTN4, activation of the PI3K-Akt pathway in endometriosis may facilitate enhanced cytoplasmic expression of ACTN4, and may contribute the cell motility and invasion observed in endometriosis.
Positive_regulation (enhanced) of Gene_expression (expression) of ACTN4 associated with endometriosis
2) Confidence 0.42 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 1.07 Pain Relevance 0.41
Enhanced cytoplasmic expression of ACTN4 is related to increased cell motility and invasion [51] and ACTN4 has recently been implicated in breast, lung, colorectal and ovarian cancers [52-54].
Positive_regulation (Enhanced) of Gene_expression (expression) of ACTN4 in lung associated with ovarian cancer
3) Confidence 0.42 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 1.22 Pain Relevance 0.45
Interestingly, enhanced cytoplasmic expression of ACTN4 is observed in about 60% of endometrioid and clear cell ovarian cancers [54], both of which have been suggested to possibly arise, at least in some cases, from endometriosis.
Positive_regulation (enhanced) of Gene_expression (expression) of ACTN4 associated with endometriosis and ovarian cancer
4) Confidence 0.42 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 1.12 Pain Relevance 0.42

General Comments

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