INT257755

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.60
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 4.97
Pain Relevance 1.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SHC1) mitochondrion (SHC1) aging (SHC1)
plasma membrane (SHC1) nucleus (SHC1) cytoplasm (SHC1)
SHC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 540 99.84 Very High Very High Very High
pain pelvic 10 75.64 Quite High
Inflammation 5 51.64 Quite High
cytokine 5 5.00 Very Low Very Low Very Low
Thalamus 5 5.00 Very Low Very Low Very Low
Dismenorea 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometriosis 690 99.84 Very High Very High Very High
Endometroid Carcinoma 5 92.08 High High
Disease 55 84.84 Quite High
Carcinoma 15 84.16 Quite High
Cancer 15 83.40 Quite High
Ovarian Cancer 75 77.68 Quite High
Reprotox - General 3 20 76.16 Quite High
INFLAMMATION 5 51.64 Quite High
Myelodysplastic Syndromes 10 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also demonstrate upregulation of SHC1 and activation of its downstream pathway, MAPK pathway (discussed below).
Positive_regulation (upregulation) of SHC1
1) Confidence 0.60 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 0.94 Pain Relevance 0.43
Furthermore, the proto-oncogenes AXL, SHC1, and JUND are elevated in endometriosis (Table 2).
Positive_regulation (elevated) of SHC1 associated with endometriosis
2) Confidence 0.40 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 0.90 Pain Relevance 0.38
IGF2, ACTN4, AXL, and SHC1 were among the most upregulated genes.
Positive_regulation (upregulated) of SHC1
3) Confidence 0.40 Published 2008 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2615013 Disease Relevance 1.27 Pain Relevance 0.46
The MAPK pathway is therefore constitutively activated in both human endometriosis and in the mouse endometriosis model, and the overexpression of SHC1 is an intriguing mechanism for the activation of this pathway in human endometriosis (Fig. 3).
Positive_regulation (activation) of SHC1 associated with endometriosis
4) Confidence 0.40 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 1.13 Pain Relevance 0.41
Similar to what we observed for AXL, SHC1 was found consistently elevated in the studied endometriotic samples.
Positive_regulation (elevated) of SHC1 associated with endometriosis
5) Confidence 0.40 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 0.74 Pain Relevance 0.19

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox