INT257762

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Context Info
Confidence 0.32
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.70
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (GAS6) signal transduction (GAS6) extracellular space (GAS6)
extracellular region (GAS6)
Anatomy Link Frequency
endometrium 1
GAS6 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 324 99.52 Very High Very High Very High
pain pelvic 6 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Thalamus 3 5.00 Very Low Very Low Very Low
Dismenorea 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometriosis 414 99.52 Very High Very High Very High
Cancer 9 86.16 High High
Ovarian Cancer 45 84.80 Quite High
Disease 33 57.12 Quite High
Carcinoma 9 43.92 Quite Low
Endometroid Carcinoma 3 5.84 Low Low
Reprotox - General 3 12 5.00 Very Low Very Low Very Low
Myelodysplastic Syndromes 6 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 6 5.00 Very Low Very Low Very Low
Reprotox - General 1 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As the PI3K-Akt pathway is involved in cell survival, proliferation, and migration, its activation through GAS6/AXL may be a common central biological event during the pathogenesis of endometriosis.
Positive_regulation (activation) of GAS6 associated with endometriosis
1) Confidence 0.32 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 0.82 Pain Relevance 0.24
GAS6, a ligand of TAM family, was also found to be upregulated in two of three endometriotic SAGE libraries compared with eutopic endometrium.
Positive_regulation (upregulated) of GAS6 in endometrium associated with endometriosis
2) Confidence 0.22 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 0.97 Pain Relevance 0.30
Overexpression of both AXL and GAS6 in ovarian endometriosis has previously been demonstrated using RT-PCR analysis and IHC [44].
Positive_regulation (Overexpression) of GAS6 associated with endometriosis
3) Confidence 0.09 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 0.91 Pain Relevance 0.27

General Comments

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