INT257763

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Context Info
Confidence 0.32
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 3.40
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (GAS6) signal transduction (GAS6) extracellular space (GAS6)
extracellular region (GAS6)
GAS6 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 432 99.52 Very High Very High Very High
pain pelvic 8 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Thalamus 4 5.00 Very Low Very Low Very Low
Dismenorea 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometriosis 552 99.52 Very High Very High Very High
Cancer 12 98.24 Very High Very High Very High
Ovarian Cancer 60 97.56 Very High Very High Very High
Disease 44 51.40 Quite High
Carcinoma 12 30.08 Quite Low
Reprotox - General 3 16 5.00 Very Low Very Low Very Low
Myelodysplastic Syndromes 8 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 8 5.00 Very Low Very Low Very Low
Reprotox - General 1 4 5.00 Very Low Very Low Very Low
Gynecological Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, it is possible that overexpression of AXL and GAS6 is a main cause for the activation of the PI3K-Akt pathway in endometriosis.
Spec (possible) Positive_regulation (overexpression) of Gene_expression (overexpression) of GAS6 associated with endometriosis
1) Confidence 0.32 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 0.79 Pain Relevance 0.24
Overexpression of both AXL and GAS6 in ovarian endometriosis has previously been demonstrated using RT-PCR analysis and IHC [44].
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of GAS6 associated with endometriosis
2) Confidence 0.32 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 0.91 Pain Relevance 0.27
Therefore, it is possible that overexpression of AXL and GAS6 is a main cause for the activation of the PI3K-Akt pathway in endometriosis.
Positive_regulation (cause) of Gene_expression (overexpression) of GAS6 associated with endometriosis
3) Confidence 0.23 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 0.79 Pain Relevance 0.24
Co-overexpression of AXL with Gas6 has also been reported in several types of tumors including ovarian cancer [45], and may therefore have an important role in uncontrolled cell growth/proliferation.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Gas6 associated with cancer and ovarian cancer
4) Confidence 0.23 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 0.91 Pain Relevance 0.28

General Comments

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