INT257764

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Context Info
Confidence 0.44
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.72
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PIK3CA) signal transduction (PIK3CA)
Anatomy Link Frequency
cleavage 2
PIK3CA (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 108 99.36 Very High Very High Very High
Inflammation 41 84.16 Quite High
chemokine 99 50.00 Quite Low
metalloproteinase 6 50.00 Quite Low
agonist 1 32.76 Quite Low
cva 3 25.52 Quite Low
antagonist 9 14.36 Low Low
Central nervous system 25 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
Angina 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometriosis 138 99.36 Very High Very High Very High
Cancer 194 99.06 Very High Very High Very High
Leukemia 12 97.90 Very High Very High Very High
Death 8 96.68 Very High Very High Very High
Mantle-cell Lymphoma 1 90.08 High High
Multiple Myeloma 1 88.16 High High
INFLAMMATION 48 84.16 Quite High
Advanced Or Metastatic Breast Cancer 28 80.68 Quite High
Ovarian Cancer 100 76.68 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 4 67.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate a role for PI3K activation in the signalling of both AA and PMA to produce MMP-9.
Positive_regulation (role) of Positive_regulation (activation) of PI3K
1) Confidence 0.44 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0 Pain Relevance 0
It was shown that in leukemia cells, several growth and survival factors from the tumor microenvironment, including CXCR4 activation, induce PI3K activation.
Positive_regulation (induce) of Positive_regulation (activation) of PI3K associated with leukemia and cancer
2) Confidence 0.32 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.37 Pain Relevance 0
MMP-9 production in response to LPS-induced PI3K stimulation has also been reported to occur through IKK?
Positive_regulation (induced) of Positive_regulation (stimulation) of PI3K
3) Confidence 0.31 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0.30 Pain Relevance 0.07
Therefore, it is possible that overexpression of AXL and GAS6 is a main cause for the activation of the PI3K-Akt pathway in endometriosis.
Positive_regulation (cause) of Positive_regulation (activation) of PI3K associated with endometriosis
4) Confidence 0.26 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 0.79 Pain Relevance 0.24
Despite documented HER2 receptor amplification, patients may have de novo or acquired resistance to trastuzumab. 39 Potential mechanisms of trastuzumab resistance include altered receptor┬ľantibody interaction (MUC4, p95HER2, ErbB2 mutations), altered downstream signaling (reduced p27, reduced PTEN, activation of PI3K, activation of Akt) and crosstalk with other signaling pathways (IGF-R1, ER, VEGFR).40 The p95HER2 receptor is created either by cleavage and shedding of the extracellular domain of the HER2 receptor or by specific mRNA splicing, resulting in a constitutively active truncated receptor which is associated with a more aggressive phenotype.
Positive_regulation (activation) of Positive_regulation (activation) of PI3K in cleavage
5) Confidence 0.09 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004582 Disease Relevance 0.26 Pain Relevance 0

General Comments

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