INT257784

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.96
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (AR) transport (AR) enzyme binding (AR)
DNA binding (AR) cell-cell signaling (AR) cytoplasm (AR)
Anatomy Link Frequency
nucleus 4
AR (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 1 96.88 Very High Very High Very High
antagonist 8 96.32 Very High Very High Very High
cytokine 1 92.60 High High
withdrawal 28 70.48 Quite High
palliative 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 107 91.48 High High
Prostate Cancer 124 85.84 High High
Opiate Addiction 2 12.72 Low Low
Metastasis 40 5.00 Very Low Very Low Very Low
Disease 39 5.00 Very Low Very Low Very Low
Apoptosis 16 5.00 Very Low Very Low Very Low
Hypersensitivity 8 5.00 Very Low Very Low Very Low
Hyperplasia 4 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Reproductive System Disorders 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The IL-1 stimulation of mitogen-activated protein/ERK kinase kinases (MEKK) results in phosphorylation of TAB2, an AR-interacting protein, which resulted in and release of the TAB2/N-CoR holocorepressor complex from the androgen receptor.
Positive_regulation (results) of Phosphorylation (phosphorylation) of AR
1) Confidence 0.45 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2615041 Disease Relevance 0.38 Pain Relevance 0.21
In the absence of androgens, MAPK and AKT kinases may induce AR phosphorylation and activation, whereas STAT3 can bind ligand-free AR and facilitate its translocation to the nucleus.
Positive_regulation (activation) of Phosphorylation (phosphorylation) of AR in nucleus
2) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0.29 Pain Relevance 0
In the absence of androgens, MAPK and AKT kinases may induce AR phosphorylation and activation, whereas STAT3 can bind ligand-free AR and facilitate its translocation to the nucleus.
Spec (may) Positive_regulation (induce) of Phosphorylation (phosphorylation) of AR in nucleus
3) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0.29 Pain Relevance 0

General Comments

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