INT257798

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Context Info
Confidence 0.18
First Reported 2009
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.40
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gria1) transport (Gria1) endoplasmic reticulum (Gria1)
plasma membrane (Gria1) protein complex (Gria1)
Gria1 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 16 100.00 Very High Very High Very High
Serotonin 14 98.24 Very High Very High Very High
Pyramidal cell 45 89.12 High High
nMDA receptor 72 84.88 Quite High
adenocard 11 5.00 Very Low Very Low Very Low
Glutamate 11 5.00 Very Low Very Low Very Low
Hippocampus 9 5.00 Very Low Very Low Very Low
Action potential 7 5.00 Very Low Very Low Very Low
ischemia 5 5.00 Very Low Very Low Very Low
potassium channel 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Epilepsy 10 76.28 Quite High
Convulsion 34 68.80 Quite High
Targeted Disruption 9 67.52 Quite High
Neurodegenerative Disease 2 52.88 Quite High
Motor Neuron Diseases 14 5.00 Very Low Very Low Very Low
Cancer 9 5.00 Very Low Very Low Very Low
Sprains And Strains 6 5.00 Very Low Very Low Very Low
Schizophrenia 5 5.00 Very Low Very Low Very Low
Death 5 5.00 Very Low Very Low Very Low
Infection 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because either enhanced excitation or reduced inhibition can increase the excitability of hippocampal CA3 network, we examined the mRNA levels of excitatory glutamate receptor (GluR) subunits and glutamic acid decarboxylases (GADs) expressed in the hippocampal CA3 region of the mutant mice by in situ hybridization (Fig. 7A, Table 1).
Spec (examined) Transcription (levels) of GluR associated with glutamate receptor
1) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615205 Disease Relevance 0.07 Pain Relevance 0.51
These would include mRNA transcripts of the AMPA and kainate members of the glutamate receptor family – GluR-B, GluR-5 & GluR-6 [33], the serotonin 5-HT2C receptor [45], the ?
Transcription (transcripts) of glutamate receptor associated with glutamate receptor and serotonin
2) Confidence 0.06 Published 2009 Journal Mol Brain Section Body Doc Link PMC2694175 Disease Relevance 0.33 Pain Relevance 0.10

General Comments

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