INT2578

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Context Info
Confidence 0.48
First Reported 1975
Last Reported 2011
Negated 1
Speculated 3
Reported most in Abstract
Documents 74
Total Number 79
Disease Relevance 33.57
Pain Relevance 12.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins1) extracellular region (Ins1) carbohydrate metabolic process (Ins1)
cytoplasm (Ins1)
Anatomy Link Frequency
adipocytes 5
plasma 3
blood 3
fat 2
body 2
Ins1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 16 100.00 Very High Very High Very High
Somatostatin 3 100.00 Very High Very High Very High
tolerance 135 99.90 Very High Very High Very High
Chronic pancreatitis 6 99.84 Very High Very High Very High
Morphine 22 99.76 Very High Very High Very High
Clonidine 4 99.64 Very High Very High Very High
Central nervous system 114 99.56 Very High Very High Very High
opiate 5 99.52 Very High Very High Very High
agonist 84 99.44 Very High Very High Very High
Enkephalin 3 99.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 1013 100.00 Very High Very High Very High
Insulin Resistance 188 100.00 Very High Very High Very High
Obesity 162 100.00 Very High Very High Very High
Urological Neuroanatomy 12 99.94 Very High Very High Very High
Sprains And Strains 77 99.92 Very High Very High Very High
Acidosis 43 99.92 Very High Very High Very High
Impaired Glucose Tolerance 135 99.90 Very High Very High Very High
Pancreatitis 6 99.84 Very High Very High Very High
Hyperlipidemia 53 99.76 Very High Very High Very High
Acid Base Imbalance 74 99.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Insulin was preferentially surface bound on the PLGA nanoparticles.
Insulin Binding (bound) of
1) Confidence 0.48 Published 1999 Journal Drug Dev Ind Pharm Section Abstract Doc Link 10194602 Disease Relevance 0 Pain Relevance 0
Alterations in hepatocyte insulin binding in chronic pancreatitis: effects of pancreatic polypeptide.
insulin Binding (binding) of in hepatocyte associated with chronic pancreatitis
2) Confidence 0.48 Published 1995 Journal Am. J. Surg. Section Title Doc Link 7817978 Disease Relevance 0.29 Pain Relevance 0.28
Insulin binding was investigated in chronic pancreatitis induced by infusion of oleic acid into the pancreatic duct of rats.
Insulin Binding (binding) of in pancreatic duct associated with chronic pancreatitis
3) Confidence 0.48 Published 1995 Journal Am. J. Surg. Section Abstract Doc Link 7817978 Disease Relevance 0.36 Pain Relevance 0.27
The effects of various agents on the binding and degradation of 125I-labelled insulin by isolated rat hepatocytes and cultured H4 hepatoma cells were studied.
insulin Binding (binding) of in hepatocytes associated with hepatocellular cancer
4) Confidence 0.48 Published 1979 Journal Can. J. Biochem. Section Abstract Doc Link 476501 Disease Relevance 0.25 Pain Relevance 0.09
Effect of acidosis on insulin binding and glucose uptake in isolated rat adipocytes.
insulin Binding (binding) of in adipocytes associated with acidosis and obesity
5) Confidence 0.48 Published 1993 Journal Tohoku J. Exp. Med. Section Title Doc Link 8248912 Disease Relevance 0.58 Pain Relevance 0.08
Evidence from others suggests that endogenous opioids may mediate the palatable properties of foods, and insulin may decrease nonfood-related reward via interaction with some CNS kappa opioid systems.
insulin Binding (interaction) of in CNS associated with endogenous opioid, central nervous system and opioid
6) Confidence 0.48 Published 2002 Journal Peptides Section Abstract Doc Link 12535697 Disease Relevance 0 Pain Relevance 0.60
In the present study we examined the ability of insulin to interact with exogenous or endogenous kappa opioids to modulate feeding of palatable sucrose pellets by nondeprived rats.
insulin Spec (examined) Binding (interact) of associated with opioid
7) Confidence 0.48 Published 2002 Journal Peptides Section Abstract Doc Link 12535697 Disease Relevance 0 Pain Relevance 0.61
The three groups were studied 15 days after the administration of STZ (n = 9), or vehicle (n = 8), or STZ associated with insulin (n = 8).


insulin Binding (associated) of
8) Confidence 0.47 Published 2006 Journal Cardiovasc Diabetol Section Body Doc Link PMC1698470 Disease Relevance 0.50 Pain Relevance 0
Marked interference by chronic hyperinsulinemia suggests that the receptor center estimates the metabolic status of the animal through means related to physicochemical binding of insulin to specific receptors.
insulin Binding (binding) of associated with hyperinsulinism
9) Confidence 0.47 Published 1975 Journal Diabetes Section Abstract Doc Link 1132600 Disease Relevance 0.21 Pain Relevance 0.36
Their low affinity for insulin provides the basis for a minor feedback action by this hormone at concentrations exceeding the normal circulating levels.
insulin Binding (affinity) of
10) Confidence 0.45 Published 1990 Journal Diabetologia Section Abstract Doc Link 2076797 Disease Relevance 0 Pain Relevance 0.08
Effect of chronic morphine administration on glucose tolerance and insulin binding to isolated rat adipocytes.
insulin Binding (binding) of in adipocytes associated with obesity, tolerance, impaired glucose tolerance and morphine
11) Confidence 0.45 Published 2001 Journal Endocr. Res. Section Title Doc Link 11428713 Disease Relevance 0.48 Pain Relevance 0.50
An increase in the maximal specific binding of 125I-labeled insulin to unit membrane area of adipocytes was observed in the experimental group (p < 0.01).
insulin Binding (binding) of in adipocytes associated with obesity
12) Confidence 0.45 Published 2001 Journal Endocr. Res. Section Abstract Doc Link 11428713 Disease Relevance 0.43 Pain Relevance 0.46
Insulin and the constituent branches of the hepatic vagus interact to modulate hypothalamic and limbic neuropeptide mRNA expression differentially.
Insulin Binding (interact) of associated with neuropeptide
13) Confidence 0.44 Published 2008 Journal J. Neuroendocrinol. Section Title Doc Link 18638024 Disease Relevance 0.23 Pain Relevance 0.39
On rechallenge with insulin and glucose, blood pressure again rose and then decreased after termination of the insulin and glucose administration.
insulin Binding (rechallenge) of in blood
14) Confidence 0.37 Published 1994 Journal Hypertension Section Abstract Doc Link 8206584 Disease Relevance 0.18 Pain Relevance 0.15
CONCLUSIONS: In the Zucker obese rat, peripheral adipose tissue removes as much insulin from the blood as the liver does, in contrast with lean rats, in which the latter is responsible for practically all insulin extraction.


insulin Binding (extraction) of in liver
15) Confidence 0.37 Published 1996 Journal Int. J. Obes. Relat. Metab. Disord. Section Body Doc Link 8880351 Disease Relevance 0.10 Pain Relevance 0
Catecholamines released into the inferior vena cava following insulin injection were separated by HPLC and measured by electrochemical detection.
insulin Binding (injection) of in inferior vena cava associated with catecholamine
16) Confidence 0.37 Published 1984 Journal Neurosci. Lett. Section Abstract Doc Link 6203062 Disease Relevance 0.25 Pain Relevance 0.58
METHODS: The stability of IPN in the process was appraised by measurement of the amount of undegraded insulin associated to nanoparticles, the average size and the span of IPN, as well as the release of insulin from IPN.
insulin Binding (associated) of
17) Confidence 0.37 Published 2005 Journal Yao Xue Xue Bao Section Body Doc Link 15881329 Disease Relevance 0.10 Pain Relevance 0
The reduction of the initial glucose levels versus time after intragastric insulin-loaded SLN, insulin solution and subcutaneous administration of insulin is depicted in Figure 2.
insulin-loaded Binding (intragastric) of
18) Confidence 0.36 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676823 Disease Relevance 0.10 Pain Relevance 0.03
Insulin association efficiency
Insulin Binding (association) of
19) Confidence 0.36 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676823 Disease Relevance 0 Pain Relevance 0
Insulin introduced in the lumen of the rat duodenum and colon was observed to be rapidly internalized by the epithelial cells and transferred through a transcytotic pathway via the Golgi apparatus to the interstitial space from which it reached the blood circulation (Ziv and Bendayan 2000).
Insulin Binding (internalized) of in duodenum
20) Confidence 0.36 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676823 Disease Relevance 0.07 Pain Relevance 0

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