INT257801

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Context Info
Confidence 0.35
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 5.12
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (S100a9) extracellular region (S100a9) plasma membrane (S100a9)
cytoskeleton (S100a9) nucleus (S100a9) cytoplasm (S100a9)
Anatomy Link Frequency
brain 1
neutrophil 1
S100a9 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 19 98.96 Very High Very High Very High
Arthritis 5 98.88 Very High Very High Very High
Inflammation 174 96.64 Very High Very High Very High
Pyramidal cell 45 92.40 High High
ischemia 3 91.44 High High
Hippocampus 7 89.20 High High
Inflammatory mediators 11 88.04 High High
cytokine 38 86.88 High High
medulla 1 81.92 Quite High
nMDA receptor 72 77.20 Quite High
Disease Link Frequency Relevance Heat
Cancer 38 100.00 Very High Very High Very High
Targeted Disruption 91 99.28 Very High Very High Very High
INFLAMMATION 201 98.96 Very High Very High Very High
Arthritis 7 98.88 Very High Very High Very High
Shock 6 97.80 Very High Very High Very High
Sepsis 18 96.36 Very High Very High Very High
Urinary Tract Infection 84 94.56 High High
Infection 74 94.24 High High
Cerebral Edema 1 94.12 High High
Chemotherapy-induced Neutropenia 1 92.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
S100A9 deficiency had little effect on the inflammatory responses to E.
Negative_regulation (deficiency) of S100A9 associated with inflammatory response
1) Confidence 0.35 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2954806 Disease Relevance 1.36 Pain Relevance 0.20
S100A9 KO mice were generated by target gene disruption of the Mrp14 gene as described [13] and are backcrossed six times to a C57BL/6 background.
Negative_regulation (disruption) of Mrp14 associated with targeted disruption
2) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954806 Disease Relevance 1.41 Pain Relevance 0.07
They are upregulated in many cancers, although S100A2, S100A9, and S100A11 have been reported to be tumor repressors [50].
Negative_regulation (repressors) of S100A9 associated with cancer
3) Confidence 0.21 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.20 Pain Relevance 0
The RT-QPCR analysis confirmed that neutrophil depletion in the mice significantly decreased, but did not completely abrogate the upregulation of the aforementioned genes (including S100A8, S100A9, IL-1?
Negative_regulation (decreased) of S100A9 in neutrophil
4) Confidence 0.19 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994359 Disease Relevance 0.51 Pain Relevance 0.13
1 protein was diminished to a negligible level at P14 and P21 (Fig. 2E and F).
Negative_regulation (diminished) of P14
5) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615205 Disease Relevance 0 Pain Relevance 0.17
In addition, mice lacking MRP8/MRP14 complexes are protected from endotoxin-induced lethal shock and E. coli-induced abdominal sepsis [140, 143] and exhibit reduced lesion volume, brain swelling, and inflammatory cell infiltration during cerebral ischemia [142].
Negative_regulation (lacking) of MRP14 in brain associated with inflammation, cv general 4 under development, ischemia, shock, cerebral edema and sepsis
6) Confidence 0.11 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 1.64 Pain Relevance 0.40

General Comments

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