INT257813

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Context Info
Confidence 0.14
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.55
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
platelet 1
Paf (Mus musculus)
Pain Link Frequency Relevance Heat
Multiple sclerosis 246 99.50 Very High Very High Very High
Spinal cord 3 87.16 High High
Inflammation 115 64.56 Quite High
agonist 30 36.56 Quite Low
aspirin 15 9.00 Low Low
chemokine 105 5.00 Very Low Very Low Very Low
5HT 69 5.00 Very Low Very Low Very Low
cva 45 5.00 Very Low Very Low Very Low
metalloproteinase 45 5.00 Very Low Very Low Very Low
cytokine 27 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Sclerosis 279 99.50 Very High Very High Very High
Disease 106 70.12 Quite High
Sprains And Strains 37 68.12 Quite High
INFLAMMATION 121 64.56 Quite High
Leptospirosis 46 50.00 Quite Low
Neurodegenerative Disease 24 48.76 Quite Low
Targeted Disruption 9 45.92 Quite Low
Communicable Diseases 1 28.12 Quite Low
Brain Injury 6 27.88 Quite Low
Cardiovascular Disease 9 14.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A study of Japanese MS patients found that the PAF degrading enzyme, PAF-AH, was significantly lower in the patients [189] but this was not reflected in the genotype.
Protein_catabolism (degrading) of PAF associated with multiple sclerosis
1) Confidence 0.14 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2829540 Disease Relevance 0.59 Pain Relevance 0.23
Evidence for PAF transport on platelet-derived microparticles (PMP) was reported [179], and more recently, the enzyme which degrades it, PAF-AH, was also identified on PMP [180].
Protein_catabolism (degrades) of PAF in platelet
2) Confidence 0.14 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2829540 Disease Relevance 0.24 Pain Relevance 0.12
A study of Japanese MS patients found that the PAF degrading enzyme, PAF-AH, was significantly lower in the patients [189] but this was not reflected in the genotype.
Protein_catabolism (degrading) of PAF associated with multiple sclerosis
3) Confidence 0.14 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2829540 Disease Relevance 0.58 Pain Relevance 0.23
Measurement of PAF-AH activity was performed as described [21] employing the Azwell Auto PAF-AH kit (Azwell): PAF-AH hydrolyzes the sn-2 position of the substrate [1-myristoyl-2-(4-nitrophenyl succinyl) phosphatidylcholine], a PAF (1-alkyl-2-acetyl phosphatidylcholine/1-O-alkyl-2-acetyl-sn-glycero-3-phospholine) analogue with a 4-nitrophenyl substituent, resulting in generating 4-nitrophenyl succinate, which is immediately degraded to 4-nitrophenol and subsequently measured spectrophotometrically at 405 nm.
Protein_catabolism (degraded) of PAF
4) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 0.13 Pain Relevance 0

General Comments

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