INT257817

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Context Info
Confidence 0.60
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 4.93
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (PAFAH1B1) cytosol (PAFAH1B1) transport (PAFAH1B1)
nuclear envelope (PAFAH1B1) nucleolus (PAFAH1B1) nucleus (PAFAH1B1)
PAFAH1B1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 225 93.36 High High
abdominal pain 5 76.76 Quite High
headache 5 75.76 Quite High
Inflammation 5 50.36 Quite High
Disease Link Frequency Relevance Heat
Leptospirosis 230 98.56 Very High Very High Very High
Infection 45 98.04 Very High Very High Very High
Sepsis 20 97.04 Very High Very High Very High
Hemorrhage 225 93.36 High High
Sprains And Strains 185 92.72 High High
Disease 80 82.60 Quite High
Exanthema 5 78.84 Quite High
Multiple Organ Failure 5 77.20 Quite High
Abdominal Pain 5 76.76 Quite High
Myalgia 5 76.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the patterns of the change of PAF-AH level in serum during the course of severe leptospirosis were similar in gerbils and patients (Figure 5 and Figure S6), including the levels of elevation.
Regulation (change) of PAF-AH associated with leptospirosis
1) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 0.86 Pain Relevance 0.03
Although more clinical data are required for proof, it suggested that the change of PAF-AH activity in patients' serum might be associated with different serogroups of the infectious leptospires, which may or may not lead to the life-threatening pulmonary hemorrhage.


Regulation (change) of PAF-AH associated with cva
2) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 0.89 Pain Relevance 0.19
By experimental infection to a Mongolian gerbil model, we found that although leptospiral PAF-AH contributed little to the change of PAF-AH level in gerbil sera during severe leptospirosis, the PAF-AH levels in serum were elevated along with the development of clinical manifestation, particularly, the whole course of pulmonary hemorrhage.


Regulation (change) of PAF-AH associated with leptospirosis, cva and infection
3) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 0.81 Pain Relevance 0.12
Moreover, as different sepses may have different response of PAF-AH activity, the exact role of serum PAF-AH in different kinds of sepses must be answered before undertaking any related medication, i.e. administration of recombinant serum PAF-AH [40], [41].
Regulation (role) of serum PAF-AH
4) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 1.08 Pain Relevance 0.14
Considering that leptospires are different from either Gram-positive or Gram-negative bacteria with basically unknown mechanisms of pathogenicity or virulence [1], the modulation of PAF-AH in serum might be different between the leptospirosis patients vs. other sepsis patients, for most of them were infected by typical Gram-positive or Gram-negative pathogenic bacteria [30], [38].
Regulation (modulation) of PAF-AH associated with leptospirosis and sepsis
5) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 1.30 Pain Relevance 0.22

General Comments

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