INT257820

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Context Info
Confidence 0.68
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 15
Disease Relevance 11.09
Pain Relevance 1.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (PAFAH1B1) cytosol (PAFAH1B1) transport (PAFAH1B1)
nuclear envelope (PAFAH1B1) nucleolus (PAFAH1B1) nucleus (PAFAH1B1)
Anatomy Link Frequency
blood 3
platelet 3
skin 1
PAFAH1B1 (Homo sapiens)
Pain Link Frequency Relevance Heat
abdominal pain 15 98.16 Very High Very High Very High
cva 675 97.84 Very High Very High Very High
headache 15 97.66 Very High Very High Very High
Inflammation 15 18.52 Low Low
Disease Link Frequency Relevance Heat
Leptospirosis 690 99.88 Very High Very High Very High
Exanthema 15 99.20 Very High Very High Very High
Sepsis 60 98.68 Very High Very High Very High
Abdominal Pain 15 98.16 Very High Very High Very High
Hemorrhage 675 97.84 Very High Very High Very High
Myalgia 15 97.84 Very High Very High Very High
Headache 15 97.66 Very High Very High Very High
Chills 15 97.46 Very High Very High Very High
Body Weight 15 96.96 Very High Very High Very High
Infection 135 96.62 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
L-PAF-AH contributed little PAF-AH activity to the increase of PAF-AH level in serum in the severe leptospirosis
Positive_regulation (increase) of PAF-AH associated with leptospirosis
1) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 0.81 Pain Relevance 0.15
To our knowledge, it is the first time that increased PAF-AH level in serum was reported for sepsis.
Positive_regulation (increased) of PAF-AH associated with sepsis
2) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 1.26 Pain Relevance 0.17
Although L-PAF-AH was identified as an intracellular protein, it could be released into the blood circulation after leptospira cells were lysed, and then led to the elevation of PAF-AH level in serum.
Positive_regulation (elevation) of PAF-AH in blood associated with leptospirosis
3) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 0.83 Pain Relevance 0.13
These findings could be directly related to the possible decrease of the blood platelet activation activity of PAF caused by the elevated PAF-AH catalyzed hydrolysis.
Positive_regulation (elevated) of PAF-AH in blood platelet
4) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 0.76 Pain Relevance 0.15
Therefore, L-PAF-AH might contribute little to the increase of PAF-AH level in serum for the severe leptospirosis.


Positive_regulation (increase) of PAF-AH associated with leptospirosis
5) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 0.56 Pain Relevance 0.04
Therefore, if the L-PAF-AH was the only factor for the elevation of PAF-AH level in serum, the leptospira density would be 1.1×1012/ml (5.4×1012 bacteria in 5 ml gerbil circulating blood).
Positive_regulation (elevation) of PAF-AH in blood associated with leptospirosis
6) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 0.80 Pain Relevance 0.06
The data shown in Figure 5 indicated that the serum activity of PAF-AH was elevated in the patients infected by L. interrogans serogroup Icterohaemorrhagiae, but not in those infected by L. interrogans serogroup Pyrogenes, Autumnalis, Pomona, Hebdomadis or Canicola.
Positive_regulation (elevated) of PAF-AH
7) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 0.98 Pain Relevance 0.25
By experimental infection to a Mongolian gerbil model, we found that although leptospiral PAF-AH contributed little to the change of PAF-AH level in gerbil sera during severe leptospirosis, the PAF-AH levels in serum were elevated along with the development of clinical manifestation, particularly, the whole course of pulmonary hemorrhage.


Positive_regulation (elevated) of PAF-AH associated with leptospirosis, cva and infection
8) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 0.66 Pain Relevance 0.09
As leptospirosis shows typical sepsis symptoms including chills, headache, myalgia, abdominal pain, conjunctival suffusion, and less often a skin rash [39], it was surprising to observe the elevation of PAF-AH in serum in severe leptospirosis patients (Figure 5) and gerbil models (Figure 4C).
Positive_regulation (elevation) of PAF-AH in skin associated with exanthema, abdominal pain, chills, leptospirosis, headache, myalgia and sepsis
9) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 1.39 Pain Relevance 0.27
The Leptospira interrogans virulent serogroup Icterohaemorrhagiae serovar Lai encodes a protein (LA2144), which exhibited the platelet-activating factor acetylhydrolase (PAF-AH) activity in vitro similar to that of human serum with respect to its substrate affinity and specificity and thus designated L-PAF-AH.
Positive_regulation (designated) of L-PAF-AH in platelet associated with leptospirosis
10) Confidence 0.43 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2615213 Disease Relevance 0.59 Pain Relevance 0.14
1-subunit-like” function despite its unique N-terminal 22 residues (Figure 1) and the gene encoding LA2144 was thus tentatively designated l-paf-ah for leptospiral platelet-activating factor acetylhydrolase [14].


Positive_regulation (designated) of l-paf-ah in platelet
11) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 0.36 Pain Relevance 0.06
The specificity of antibody-antigen interaction distinguishing the L-PAF-AH and the gerbil serum PAF-AH was further tested with ELISA.


Positive_regulation (gerbil) of serum PAF-AH
12) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 0.06 Pain Relevance 0
Comparing PAF-AH to the control, its changes in serum were closely associated with the whole course of pulmonary hemorrhage (Figure 4B and 4C).
Positive_regulation (Comparing) of PAF-AH associated with cva
13) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 0.62 Pain Relevance 0.07
Therefore, if the L-PAF-AH was the only factor for the elevation of PAF-AH level in serum, the leptospira density would be 1.1×1012/ml (5.4×1012 bacteria in 5 ml gerbil circulating blood).
Positive_regulation (elevation) of L-PAF-AH in blood associated with leptospirosis
14) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 0.81 Pain Relevance 0.06
There was no detectable L-PAF-AH in the 500 µl sera collected either during the increasing phase for PAF-AH in serum (on the 2nd, 3rd, 4th, 5th and 6th days) or during the decreasing phase (on the 7th, 8th and 9th days) (Figure S5).
Positive_regulation (increasing) of PAF-AH
15) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 0.60 Pain Relevance 0.05

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