INT257824

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Context Info
Confidence 0.74
First Reported 2009
Last Reported 2009
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 11
Disease Relevance 6.58
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (PAFAH1B1) cytosol (PAFAH1B1) transport (PAFAH1B1)
nuclear envelope (PAFAH1B1) nucleolus (PAFAH1B1) nucleus (PAFAH1B1)
Anatomy Link Frequency
blood 2
platelet 1
skin 1
PAFAH1B1 (Homo sapiens)
Pain Link Frequency Relevance Heat
abdominal pain 11 98.16 Very High Very High Very High
headache 11 97.66 Very High Very High Very High
cva 495 95.00 High High
Inflammation 11 67.68 Quite High
Disease Link Frequency Relevance Heat
Sprains And Strains 407 100.00 Very High Very High Very High
Leptospirosis 506 99.70 Very High Very High Very High
Exanthema 11 99.20 Very High Very High Very High
Abdominal Pain 11 98.16 Very High Very High Very High
Myalgia 11 97.84 Very High Very High Very High
Infection 99 97.68 Very High Very High Very High
Headache 11 97.66 Very High Very High Very High
Chills 11 97.46 Very High Very High Very High
Sepsis 44 96.94 Very High Very High Very High
Hemorrhage 495 95.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The data shown in Figure 5 indicated that the serum activity of PAF-AH was elevated in the patients infected by L. interrogans serogroup Icterohaemorrhagiae, but not in those infected by L. interrogans serogroup Pyrogenes, Autumnalis, Pomona, Hebdomadis or Canicola.
Localization (elevated) of PAF-AH
1) Confidence 0.74 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 0.98 Pain Relevance 0.25
As leptospirosis shows typical sepsis symptoms including chills, headache, myalgia, abdominal pain, conjunctival suffusion, and less often a skin rash [39], it was surprising to observe the elevation of PAF-AH in serum in severe leptospirosis patients (Figure 5) and gerbil models (Figure 4C).
Localization (elevation) of PAF-AH in skin associated with exanthema, abdominal pain, chills, leptospirosis, headache, myalgia and sepsis
2) Confidence 0.74 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 1.39 Pain Relevance 0.27
It is possible that not all of the activities measured in the blood of patients and gerbils with leptospirosis were from the secreted, extracellular form of PAF-AH—the resident enzyme of normal serum—but also included intracellular activity that leaked from injured or dying cells.
Localization (secreted) of PAF-AH in blood associated with leptospirosis
3) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 0.77 Pain Relevance 0
We also tried to examine whether the L-PAF-AH in L. interrogans serovar Lai strain 56601 was secreted into the medium.
Localization (secreted) of L-PAF-AH associated with sprains and strains
4) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 0.29 Pain Relevance 0
These results clearly demonstrated that L-PAF-AH is an intracellular protein, which is not released into the culture medium until the bacterial cells were autolysed.


Neg (not) Localization (released) of L-PAF-AH
5) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 0.30 Pain Relevance 0
Production of anti-L-PAF-AH rabbit polyclonal serum and murine monoclonal antibodies (MoAbs)
Localization (serum) of anti-L-PAF-AH
6) Confidence 0.64 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 0 Pain Relevance 0
Although L-PAF-AH might be released into the micro-environment via cell lysis, its PAF-AH activity apparently contributed little to this elevation.
Localization (released) of L-PAF-AH
7) Confidence 0.64 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2615213 Disease Relevance 0.41 Pain Relevance 0.13
The enzyme kinetics data were collected employing the purified rL-PAF-AH while human serum samples were used for the Km determination of human serum PAF-AH.


Spec (determination) Localization (determination) of serum PAF-AH
8) Confidence 0.64 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 0 Pain Relevance 0
We tried to make a rough estimation of L-PAF-AH released to the serum by measuring its level in an in vitro serum culture (Korthof medium).
Localization (released) of L-PAF-AH
9) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 0.82 Pain Relevance 0.13
Although L-PAF-AH was identified as an intracellular protein, it could be released into the blood circulation after leptospira cells were lysed, and then led to the elevation of PAF-AH level in serum.
Localization (released) of L-PAF-AH in blood associated with leptospirosis
10) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 0.86 Pain Relevance 0.14
On the other hand, it is still possible that the L-PAF-AH released from autolysed leptospires during mid- and late-phase of infection may function as a virulent factor within the local niche of small blood capillaries of the alveoli [14] as its substrate, PAF, a potent lipid messenger, participates in a variety of physiological events including platelet aggregation to maintain the blood homeostasis [25].
Localization (released) of L-PAF-AH in platelet associated with infection
11) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 0.76 Pain Relevance 0.08

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