INT257827

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.01
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Stap1) nucleolus (Stap1) nucleus (Stap1)
cytoplasm (Stap1)
Anatomy Link Frequency
NK cells 1
T cells 1
Stap1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Arthritis 18 5.00 Very Low Very Low Very Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Agammaglobulinemia 126 91.52 High High
Bacterial Infection 12 89.24 High High
Infection 48 89.20 High High
Disease 34 52.72 Quite High
Otitis Media 18 5.00 Very Low Very Low Very Low
Infectious Arthritis 18 5.00 Very Low Very Low Very Low
Pneumonia 18 5.00 Very Low Very Low Very Low
Hepatitis B Virus Infection 14 5.00 Very Low Very Low Very Low
Immunodeficiency 14 5.00 Very Low Very Low Very Low
Sinusitis 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been shown to be caused by a variety of mutations in the gene encoding Bruton tyrosine kinase (BTK).1-3 BTK is a signal-transducing protein expressed in all hematopoietic lineages, except in T cells and NK cells.2 It is composed of five distinct structural domains: the pleckstrin homology (PH), Tec homology (TH), Src homology (SH) 3, SH2, and catalytic kinase (SH1) domains.4 XLA is often characterized by recurrent bacterial infections due to a decrease in the number of B cells and a subsequent reduction in the level of serum immunoglobulin.2,3,5,6 The BTK gene has been mapped to Xq21.3-Xq22, encompassing 37.5 kb and containing 19 exons, and mutations in the gene are inherited in an X-linked recessive pattern.7
Neg (except) Gene_expression (expressed) of signal-transducing protein in NK cells associated with bacterial infection and agammaglobulinemia
1) Confidence 0.01 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615253 Disease Relevance 0.50 Pain Relevance 0
It has been shown to be caused by a variety of mutations in the gene encoding Bruton tyrosine kinase (BTK).1-3 BTK is a signal-transducing protein expressed in all hematopoietic lineages, except in T cells and NK cells.2 It is composed of five distinct structural domains: the pleckstrin homology (PH), Tec homology (TH), Src homology (SH) 3, SH2, and catalytic kinase (SH1) domains.4 XLA is often characterized by recurrent bacterial infections due to a decrease in the number of B cells and a subsequent reduction in the level of serum immunoglobulin.2,3,5,6 The BTK gene has been mapped to Xq21.3-Xq22, encompassing 37.5 kb and containing 19 exons, and mutations in the gene are inherited in an X-linked recessive pattern.7
Neg (except) Gene_expression (expressed) of signal-transducing protein in T cells associated with bacterial infection and agammaglobulinemia
2) Confidence 0.00 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615253 Disease Relevance 0.50 Pain Relevance 0

General Comments

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