INT257834

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Context Info
Confidence 0.65
First Reported 2008
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.45
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Btk) cytosol (Btk) plasma membrane (Btk)
nucleus (Btk) kinase activity (Btk) cytoplasm (Btk)
Anatomy Link Frequency
NK cells 2
T cells 2
lymphocyte 1
Btk (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 36 5.00 Very Low Very Low Very Low
rheumatoid arthritis 9 5.00 Very Low Very Low Very Low
Central nervous system 7 5.00 Very Low Very Low Very Low
cINOD 5 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
Potency 5 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Agammaglobulinemia 253 100.00 Very High Very High Very High
Obesity 233 94.28 High High
Infection 98 89.92 High High
Bacterial Infection 24 89.24 High High
Hyperplasia 4 84.96 Quite High
Sarcoma 1 78.36 Quite High
Solid Tumor 1 69.88 Quite High
Disorder Of Lipid Metabolism 39 63.60 Quite High
Myeloid Leukemia 85 60.88 Quite High
Disease 80 52.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The sections were incubated in the biotinylated secondary antibody (anti-rat-IgG peroxidase conjugate, Sigma, St.
Gene_expression (conjugate) of xid
1) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2898800 Disease Relevance 0 Pain Relevance 0
and Kit at nanomolar to sub-nanomolar concentrations (Table 1).11 Recently, dasatinib was also shown to bind to other tyrosine and serine/threonine kinases, such as the TEC family kinases, BTK and TEC, the mitogen-activated protein kinases, the receptor tyrosine kinase, discoidin domain receptor 1 and the ephrin receptors.12
Gene_expression (kinases) of BTK
2) Confidence 0.29 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886328 Disease Relevance 0.29 Pain Relevance 0
It has been shown to be caused by a variety of mutations in the gene encoding Bruton tyrosine kinase (BTK).1-3 BTK is a signal-transducing protein expressed in all hematopoietic lineages, except in T cells and NK cells.2 It is composed of five distinct structural domains: the pleckstrin homology (PH), Tec homology (TH), Src homology (SH) 3, SH2, and catalytic kinase (SH1) domains.4 XLA is often characterized by recurrent bacterial infections due to a decrease in the number of B cells and a subsequent reduction in the level of serum immunoglobulin.2,3,5,6 The BTK gene has been mapped to Xq21.3-Xq22, encompassing 37.5 kb and containing 19 exons, and mutations in the gene are inherited in an X-linked recessive pattern.7
Neg (except) Gene_expression (expressed) of BTK in NK cells associated with bacterial infection and agammaglobulinemia
3) Confidence 0.25 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615253 Disease Relevance 0.51 Pain Relevance 0
It has been shown to be caused by a variety of mutations in the gene encoding Bruton tyrosine kinase (BTK).1-3 BTK is a signal-transducing protein expressed in all hematopoietic lineages, except in T cells and NK cells.2 It is composed of five distinct structural domains: the pleckstrin homology (PH), Tec homology (TH), Src homology (SH) 3, SH2, and catalytic kinase (SH1) domains.4 XLA is often characterized by recurrent bacterial infections due to a decrease in the number of B cells and a subsequent reduction in the level of serum immunoglobulin.2,3,5,6 The BTK gene has been mapped to Xq21.3-Xq22, encompassing 37.5 kb and containing 19 exons, and mutations in the gene are inherited in an X-linked recessive pattern.7
Neg (except) Gene_expression (expressed) of BTK in NK cells associated with bacterial infection and agammaglobulinemia
4) Confidence 0.25 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615253 Disease Relevance 0.51 Pain Relevance 0
Genes that belong to this pathway are Toll-like receptor 5, 7, and 8 (TLR5, TLR7, TLR8), CD14 molecule (CD14), lymphocyte antigen 96 (LY96; also known as MD-2), Bruton agammaglobulinemia tyrosine kinase (BTK) [29], and myeloid differentiation primary response gene (88) (Myd88).
Gene_expression (molecule) of BTK in lymphocyte associated with agammaglobulinemia
5) Confidence 0.17 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2925326 Disease Relevance 1.14 Pain Relevance 0
It has been shown to be caused by a variety of mutations in the gene encoding Bruton tyrosine kinase (BTK).1-3 BTK is a signal-transducing protein expressed in all hematopoietic lineages, except in T cells and NK cells.2 It is composed of five distinct structural domains: the pleckstrin homology (PH), Tec homology (TH), Src homology (SH) 3, SH2, and catalytic kinase (SH1) domains.4 XLA is often characterized by recurrent bacterial infections due to a decrease in the number of B cells and a subsequent reduction in the level of serum immunoglobulin.2,3,5,6 The BTK gene has been mapped to Xq21.3-Xq22, encompassing 37.5 kb and containing 19 exons, and mutations in the gene are inherited in an X-linked recessive pattern.7
Neg (except) Gene_expression (expressed) of BTK in T cells associated with bacterial infection and agammaglobulinemia
6) Confidence 0.08 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615253 Disease Relevance 0.51 Pain Relevance 0
It has been shown to be caused by a variety of mutations in the gene encoding Bruton tyrosine kinase (BTK).1-3 BTK is a signal-transducing protein expressed in all hematopoietic lineages, except in T cells and NK cells.2 It is composed of five distinct structural domains: the pleckstrin homology (PH), Tec homology (TH), Src homology (SH) 3, SH2, and catalytic kinase (SH1) domains.4 XLA is often characterized by recurrent bacterial infections due to a decrease in the number of B cells and a subsequent reduction in the level of serum immunoglobulin.2,3,5,6 The BTK gene has been mapped to Xq21.3-Xq22, encompassing 37.5 kb and containing 19 exons, and mutations in the gene are inherited in an X-linked recessive pattern.7
Neg (except) Gene_expression (expressed) of BTK in T cells associated with bacterial infection and agammaglobulinemia
7) Confidence 0.08 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615253 Disease Relevance 0.51 Pain Relevance 0

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