INT257835

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.41
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Btk) cytosol (Btk) plasma membrane (Btk)
nucleus (Btk) kinase activity (Btk) cytoplasm (Btk)
Anatomy Link Frequency
NK cells 1
T cells 1
Btk (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 40 81.84 Quite High
Hippocampus 8 54.72 Quite High
anesthesia 2 26.80 Quite Low
aspirin 10 18.00 Low Low
isoflurane 1 12.44 Low Low
cytokine 14 11.44 Low Low
fibrosis 35 5.00 Very Low Very Low Very Low
Arthritis 28 5.00 Very Low Very Low Very Low
rheumatoid arthritis 9 5.00 Very Low Very Low Very Low
Eae 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bacterial Infection 13 98.78 Very High Very High Very High
Agammaglobulinemia 126 97.64 Very High Very High Very High
Intellectual Impairment 2 89.92 High High
Disease 44 86.08 High High
Sprains And Strains 10 83.20 Quite High
Epilepsy 1 82.96 Quite High
Autoimmune Disease 16 82.84 Quite High
INFLAMMATION 32 81.84 Quite High
Language Development Disorders 1 79.08 Quite High
Cancer 7 75.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Deparaffinization and rehydration of the 10-┬Ám paraffin sections was followed by inhibition of endogenous peroxidase and antigen retrival.
Negative_regulation (inhibition) of xid
1) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2898800 Disease Relevance 0 Pain Relevance 0
inhibitor, ATK.
Negative_regulation (inhibitor) of ATK
2) Confidence 0.30 Published 2010 Journal Respir Res Section Body Doc Link PMC2873258 Disease Relevance 0.15 Pain Relevance 0
It has been shown to be caused by a variety of mutations in the gene encoding Bruton tyrosine kinase (BTK).1-3 BTK is a signal-transducing protein expressed in all hematopoietic lineages, except in T cells and NK cells.2 It is composed of five distinct structural domains: the pleckstrin homology (PH), Tec homology (TH), Src homology (SH) 3, SH2, and catalytic kinase (SH1) domains.4 XLA is often characterized by recurrent bacterial infections due to a decrease in the number of B cells and a subsequent reduction in the level of serum immunoglobulin.2,3,5,6 The BTK gene has been mapped to Xq21.3-Xq22, encompassing 37.5 kb and containing 19 exons, and mutations in the gene are inherited in an X-linked recessive pattern.7
Negative_regulation (reduction) of BTK gene in NK cells associated with bacterial infection and agammaglobulinemia
3) Confidence 0.18 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615253 Disease Relevance 0.70 Pain Relevance 0
Inhibitors of kinases such as BTK and Fyn are not covered in this review.
Neg (not) Negative_regulation (covered) of BTK
4) Confidence 0.10 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721774 Disease Relevance 0.61 Pain Relevance 0.13
It has been shown to be caused by a variety of mutations in the gene encoding Bruton tyrosine kinase (BTK).1-3 BTK is a signal-transducing protein expressed in all hematopoietic lineages, except in T cells and NK cells.2 It is composed of five distinct structural domains: the pleckstrin homology (PH), Tec homology (TH), Src homology (SH) 3, SH2, and catalytic kinase (SH1) domains.4 XLA is often characterized by recurrent bacterial infections due to a decrease in the number of B cells and a subsequent reduction in the level of serum immunoglobulin.2,3,5,6 The BTK gene has been mapped to Xq21.3-Xq22, encompassing 37.5 kb and containing 19 exons, and mutations in the gene are inherited in an X-linked recessive pattern.7
Negative_regulation (reduction) of BTK gene in T cells associated with bacterial infection and agammaglobulinemia
5) Confidence 0.06 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615253 Disease Relevance 0.70 Pain Relevance 0
CrT deficiency is a relatively newly recognized disorder and is not routinely screened which makes estimates of the prevalence difficult to determine.
Neg (not) Negative_regulation (screened) of deficiency
6) Confidence 0.01 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020968 Disease Relevance 0.25 Pain Relevance 0.03

General Comments

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