INT257870

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Context Info
Confidence 0.18
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.50
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Agt, Akt1) nucleoplasm (Akt1) transport (Akt1)
enzyme binding (Akt1) carbohydrate metabolic process (Akt1) extracellular matrix organization (Agt)
Agt (Rattus norvegicus)
Akt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 1 100.00 Very High Very High Very High
agonist 3 86.96 High High
cytokine 1 48.64 Quite Low
Inflammation 6 48.24 Quite Low
fibrosis 14 22.80 Low Low
anesthesia 4 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Perioperative pain 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 1 100.00 Very High Very High Very High
Diabetes Mellitus 62 99.28 Very High Very High Very High
Hyperplasia 4 93.00 High High
Left Ventricular Hypertrophy 1 91.88 High High
Hyperinsulinism 1 91.20 High High
Coronary Heart Disease 10 84.88 Quite High
Hypertrophy 14 81.12 Quite High
Myocardial Infarction 78 80.16 Quite High
Cardiovascular Disease 2 76.60 Quite High
Stress 8 74.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The Akt kinase pathway is activated by various stressful stimuli such as ischemia, heat, angiotensin II and circulating insulin.
angiotensin II Positive_regulation (activated) of Akt kinase associated with ischemia
1) Confidence 0.18 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.13 Pain Relevance 0.05
Insulin and angiotensin II are known to activate the PI3K/Akt/mTOR/P70S6K pathways and to phosphorylate 4E-BP1.13-15
angiotensin II Positive_regulation (activate) of Akt
2) Confidence 0.05 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615285 Disease Relevance 0.37 Pain Relevance 0.04

General Comments

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