INT257873

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Context Info
Confidence 0.13
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.05
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins1) extracellular region (Ins1) carbohydrate metabolic process (Ins1)
cytoplasm (Ins1)
Ins1 (Rattus norvegicus)
Pik3cg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 9 86.64 High High
withdrawal 3 52.36 Quite High
cytokine 3 49.12 Quite Low
Inflammation 9 48.72 Quite Low
ketamine 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperplasia 12 93.48 High High
Hyperinsulinism 3 91.68 High High
Cardiovascular Disease 6 77.08 Quite High
Neointima 33 76.68 Quite High
Injury 48 75.08 Quite High
Diabetes Mellitus 21 56.64 Quite High
Vasculitis 6 54.44 Quite High
Adhesions 3 51.52 Quite High
INFLAMMATION 9 48.72 Quite Low
Hyperglycemia 6 38.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PI3K and MAPK are upstream molecules and related to the insulin-mediated signaling pathway, and insulin can activate PI3K through the phosphorylation of IRS1/2 or MAPK by Ras-GTP.
insulin Positive_regulation (activate) of PI3K
1) Confidence 0.13 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615285 Disease Relevance 0.68 Pain Relevance 0.03
Insulin and angiotensin II are known to activate the PI3K/Akt/mTOR/P70S6K pathways and to phosphorylate 4E-BP1.13-15
Insulin Positive_regulation (activate) of PI3K
2) Confidence 0.09 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615285 Disease Relevance 0.37 Pain Relevance 0.04
PI3K and a variety of downstream protein kinases, including Akt and p70S6K, represent 1 of the major signaling pathways mediating the metabolic effects of insulin.17,18 In the present study, the PI3K signaling pathway in primary cultured RAoSMCs was rapidly and markedly activated in response to insulin.
insulin Positive_regulation (activated) of PI3K
3) Confidence 0.09 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615285 Disease Relevance 0 Pain Relevance 0.04

General Comments

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