INT257893

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sostdc1) extracellular region (Sostdc1)
Anatomy Link Frequency
nucleus accumbens 2
Sostdc1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nicotine 139 100.00 Very High Very High Very High
Dopamine 27 100.00 Very High Very High Very High
Nucleus accumbens 12 100.00 Very High Very High Very High
nMDA receptor antagonist 18 80.48 Quite High
Opioid 4 74.72 Quite High
antagonist 19 72.88 Quite High
addiction 34 67.72 Quite High
tolerance 39 50.00 Quite Low
amygdala 1 48.16 Quite Low
Glutamate 25 45.76 Quite Low
Disease Link Frequency Relevance Heat
Drug Dependence 20 50.00 Quite Low
Recurrence 4 30.92 Quite Low
Nicotine Addiction 19 5.00 Very Low Very Low Very Low
Opiate Addiction 6 5.00 Very Low Very Low Very Low
Syndrome 6 5.00 Very Low Very Low Very Low
Tremor 3 5.00 Very Low Very Low Very Low
Sleep Disorders 2 5.00 Very Low Very Low Very Low
Ocular Toxicity (including Many Sub-types) 2 5.00 Very Low Very Low Very Low
Cocaine Dependence 2 5.00 Very Low Very Low Very Low
Akathisia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a series of experiments, Shoaib, Stolerman, and colleagues demonstrated that repeated co-administration of 0.3 mg/kg dizocilpine along with 0.4 mg/kg nicotine during several sensitization sessions attenuated sensitization to the locomotor stimulant effect of nicotine.87,88 This co-administration of dizocilpine also prevented sensitization of nicotine-induced dopamine release in the nucleus accumbens and the sensitized increase in nicotinic receptors in a variety of areas, including the nucleus accumbens,65 that normally occurs with repeated injections of nicotine.
Negative_regulation (prevented) of Positive_regulation (increase) of sensitization in nucleus accumbens associated with nucleus accumbens, dopamine and nicotine
1) Confidence 0.01 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615322 Disease Relevance 0 Pain Relevance 0.90

General Comments

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