INT257895

Context Info Confidence 0.00 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.09 Pain Relevance 0.83

extracellular space (Sostdc1) extracellular region (Sostdc1) plasma membrane (GRIN1)

Sostdc1 (Rattus norvegicus) GRIN1 (Homo sapiens)

Pain Link Frequency Relevance Heat nMDA receptor 30 100.00 Nicotine 139 99.98 cocaine 11 98.12 nMDA receptor antagonist 18 85.40 Glutamate 25 52.88 tolerance 39 50.00 addiction 34 50.00 antagonist 19 50.00 Morphine 3 37.92 Glutamate receptor 6 32.00

Disease Link Frequency Relevance Heat Attention Deficit Hyperactivity Disorder 1 88.20 Drug Dependence 20 50.00 Nicotine Addiction 19 5.00 Opiate Addiction 6 5.00 Syndrome 6 5.00 Recurrence 4 5.00 Tremor 3 5.00 Sleep Disorders 2 5.00 Ocular Toxicity (including Many Sub-types) 2 5.00 Cocaine Dependence 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These results are consistent with previous data demonstrating that pretreatment with MK-801 blocks the development of sensitization to drugs of abuse including nicotine, cocaine, amphetamine or methamphetamine.94 Furthermore, these results also demonstrate that nicotine-induced behavioral sensitization requires the activation of NMDA receptors not only for its development, but also for its expression.

Positive_regulation (induced) of sensitization Positive_regulation (requires) of Positive_regulation (activation) of NMDA associated with nmda receptor, nicotine and cocaine

1) Confidence 0.00 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615322 Disease Relevance 0.09 Pain Relevance 0.83

General Comments

This test has worked.