INT2579

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Context Info
Confidence 0.99
First Reported 1979
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 43
Total Number 43
Disease Relevance 9.91
Pain Relevance 5.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins1) extracellular region (Ins1) carbohydrate metabolic process (Ins1)
cytoplasm (Ins1)
Anatomy Link Frequency
hepatocytes 5
plasma 4
blood 1
CSF 1
skin 1
Ins1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 13 100.00 Very High Very High Very High
metalloproteinase 17 99.98 Very High Very High Very High
lidocaine 10 99.52 Very High Very High Very High
local anesthetic 3 98.96 Very High Very High Very High
IPN 3 98.36 Very High Very High Very High
Inflammation 27 97.52 Very High Very High Very High
Bioavailability 108 94.48 High High
noradrenaline 6 92.72 High High
alcohol 19 92.00 High High
anesthesia 15 91.00 High High
Disease Link Frequency Relevance Heat
Insulin Resistance 15 100.00 Very High Very High Very High
Injury 39 99.84 Very High Very High Very High
Hepatocellular Cancer 24 99.72 Very High Very High Very High
Diabetes Mellitus 163 99.36 Very High Very High Very High
Hyperlipidemia 11 99.22 Very High Very High Very High
Obesity 31 98.56 Very High Very High Very High
Pompes Disease 6 98.08 Very High Very High Very High
Stress 11 97.94 Very High Very High Very High
Wound Healing 9 97.92 Very High Very High Very High
INFLAMMATION 31 97.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
From plasma label decay curves and insulin concentrations, the insulin pool size, half-life, and rate of degradation were calculated.
Protein_catabolism (degradation) of insulin in plasma
1) Confidence 0.99 Published 1995 Journal Endocrinology Section Abstract Doc Link 7649094 Disease Relevance 0.31 Pain Relevance 0.21
Similarly, tosyl-L-lysyl chloromethyl ketone selectively inhibited the degradation of 125I-labelled insulin by isolated hepatocytes, as did the sulfhydryl reagents, p-hydroxy- and p-chloromercuriphenyl sulfonic acid.
Protein_catabolism (degradation) of insulin in hepatocytes
2) Confidence 0.99 Published 1979 Journal Can. J. Biochem. Section Abstract Doc Link 476501 Disease Relevance 0.26 Pain Relevance 0.09
Mode of uptake and degradation of 125I-labelled insulin by isolated hepatocytes and H4 hepatoma cells.
Protein_catabolism (degradation) of insulin in hepatocytes associated with hepatocellular cancer
3) Confidence 0.99 Published 1979 Journal Can. J. Biochem. Section Title Doc Link 476501 Disease Relevance 0.28 Pain Relevance 0.09
Various lysosomotropic agents, including chloroquine, ammonium chloride, and the topical anesthetics, lidocaine and procaine inhibited insulin degradation by H4 hepatoma cells but had little effect on the binding of the hormone.
Protein_catabolism (degradation) of insulin associated with hepatocellular cancer and lidocaine
4) Confidence 0.99 Published 1979 Journal Can. J. Biochem. Section Abstract Doc Link 476501 Disease Relevance 0.27 Pain Relevance 0.10
Lectins and antimicrotubular agents, which are known to affect the mobility of plasma membrane proteins or of intracytoplasmic vesicles, selectively inhibited insulin degradation by hepatocytes to varying degrees, whereas agents which inhibit the function of microfilaments had no effect.
Protein_catabolism (degradation) of insulin in plasma
5) Confidence 0.99 Published 1979 Journal Can. J. Biochem. Section Abstract Doc Link 476501 Disease Relevance 0.21 Pain Relevance 0.07
Inhibitors of energy production, including sodium fluoride, sodium azide, and dinitrophenol, also selectively inhibited the degradation of insulin by hepatocytes, although cyanide had no effect under the conditions used.
Protein_catabolism (degradation) of insulin in hepatocytes
6) Confidence 0.99 Published 1979 Journal Can. J. Biochem. Section Abstract Doc Link 476501 Disease Relevance 0.24 Pain Relevance 0.08
Thus, the blood glucose-lowering action of racecadotril was related to insulin secretion, but not through the inhibition of plasma insulin degradation.
Protein_catabolism (degradation) of insulin in plasma
7) Confidence 0.97 Published 2010 Journal Horm. Metab. Res. Section Abstract Doc Link 20143290 Disease Relevance 0 Pain Relevance 0.17
Coinfusion with an excess of unlabeled insulin impaired the clearance and degradation of labeled insulin.
Protein_catabolism (degradation) of insulin
8) Confidence 0.89 Published 1990 Journal Peptides Section Abstract Doc Link 2188232 Disease Relevance 0 Pain Relevance 0
Small amounts of degraded insulin appeared in the CSF.
Protein_catabolism (degraded) of insulin in CSF
9) Confidence 0.89 Published 1990 Journal Peptides Section Abstract Doc Link 2188232 Disease Relevance 0 Pain Relevance 0
The post-receptor biosynthetic processes involved in the expression of the biological activities of insulin (syntheses of glycogen, protein, lipid) require energy produced by oxidative metabolism while the degradation of insulin is carried out by nonlysosomal mechanisms which are not energy-requiring.
Protein_catabolism (degradation) of insulin
10) Confidence 0.88 Published 1985 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 3904755 Disease Relevance 0.12 Pain Relevance 0.10
While exposure of cultures to the amines, monodansylcadaverine or CH3NH2, resulted in significant dose-dependent decreases in glycogenesis, only monodansylcadaverine (an inhibitor of receptor clustering) decreased uptake whereas CH3NH2 (a lysosomotropic agent) caused increases in both insulin uptake and degradation.
Protein_catabolism (degradation) of insulin associated with pompes disease
11) Confidence 0.88 Published 1985 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 3904755 Disease Relevance 0.19 Pain Relevance 0.17
Incubation of primary cultures of rat hepatocytes with the local anesthetics, procaine or lidocaine, had little or no effect on insulin uptake or degradation but caused an inhibition of insulin-stimulated glycogenesis.
Protein_catabolism (degradation) of insulin in hepatocytes associated with pompes disease, lidocaine and local anesthetic
12) Confidence 0.88 Published 1985 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 3904755 Disease Relevance 0.18 Pain Relevance 0.20
METHODS: The stability of IPN in the process was appraised by measurement of the amount of undegraded insulin associated to nanoparticles, the average size and the span of IPN, as well as the release of insulin from IPN.
Protein_catabolism (undegraded) of insulin
13) Confidence 0.87 Published 2005 Journal Yao Xue Xue Bao Section Body Doc Link 15881329 Disease Relevance 0.10 Pain Relevance 0
At temperatures below 20 degrees C, insulin degradation was negligible but rose rapidly between 20 and 37 degrees C, suggesting that a membrane-related step is rate limiting in the overall degradative process.
Protein_catabolism (degradation) of insulin
14) Confidence 0.87 Published 1979 Journal Can. J. Biochem. Section Abstract Doc Link 476501 Disease Relevance 0.20 Pain Relevance 0.06
Previous investigators have shown that insulin is degraded in experimental wounds, suggesting that the action of insulin may be locally modified.
Protein_catabolism (degraded) of insulin associated with injury
15) Confidence 0.82 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9357792 Disease Relevance 0.42 Pain Relevance 0.11
Multiple proteinases appear to participate in the overall degradation of insulin in WF.
Protein_catabolism (degradation) of insulin
16) Confidence 0.82 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9357792 Disease Relevance 0.41 Pain Relevance 0.18
However, the primary enzyme responsible for insulin degradation in WF was characterized by immunoprecipitation and immunoblotting and identified as the neutral thiol-dependent metalloproteinase, insulin-degrading enzyme (EC 3.4.24.56).
Protein_catabolism (degradation) of insulin associated with metalloproteinase
17) Confidence 0.82 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9357792 Disease Relevance 0.40 Pain Relevance 0.18
Glucagon and adrenocorticotrophin degradation was also observed, whereas minimal degradation of insulin-like growth factors I and II and epidermal growth factor was detected in WF.
Protein_catabolism (degradation) of insulin
18) Confidence 0.82 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9357792 Disease Relevance 0.34 Pain Relevance 0.16
The following study corroborates these findings and identifies the major proteinase responsible for insulin degradation in wound fluid (WF).
Protein_catabolism (degradation) of insulin associated with injury
19) Confidence 0.82 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9357792 Disease Relevance 0.43 Pain Relevance 0.16
The ability to extracellularly degrade insulin may represent a unique mechanism for the regulation of this hormone's role in healing wounds.
Protein_catabolism (degrade) of insulin associated with injury
20) Confidence 0.82 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9357792 Disease Relevance 0.41 Pain Relevance 0.14

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