INT257931

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Context Info
Confidence 0.26
First Reported 2008
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 5.12
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
B cells 1
striatum 1
DCs 1
H2 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 16 99.98 Very High Very High Very High
imagery 49 89.76 High High
dopaminergic neurodegeneration 4 89.48 High High
Potency 1 87.76 High High
Deep tissue 2 79.76 Quite High
cytokine 25 79.68 Quite High
Serotonin 4 45.56 Quite Low
Dopamine 46 44.04 Quite Low
Analgesic 1 37.16 Quite Low
antagonist 18 31.08 Quite Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 357 99.72 Very High Very High Very High
Sprains And Strains 165 97.16 Very High Very High Very High
Movement Disorders 8 94.24 High High
Disease 292 93.40 High High
Acute Disease 1 93.08 High High
Drug Induced Neurotoxicity 28 91.24 High High
Stress 88 89.12 High High
Syndrome 8 87.40 High High
Targeted Disruption 20 85.56 High High
Injury 8 74.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We could detect the change in H2 in the striatum during the inhalation of H2 (Figure S2).
Regulation (change) of H2 in striatum
1) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 0 Pain Relevance 0
Though the effects of H2 water on behavioral response were not tested in older mice in the current study, our results raised a possibility that H2 water may reduce the movement disorder in PD patients.
Regulation (effects) of H2 associated with movement disorders and disease
2) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 1.95 Pain Relevance 0.04
The effect of H2 water in chronic MPTP infusion model
Regulation (effect) of H2 associated with parkinson's disease
3) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 1.34 Pain Relevance 0
H2 values were indeed significantly higher than in human populations, in particular for SBP, HR and ECG intervals (see for instance [36], [37] and [38]), where H2 estimates typically vary around 0.6 in twin studies and around 0.25 in nuclear families.
Regulation (values) of H2
4) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722085 Disease Relevance 0.32 Pain Relevance 0
Specifically, the expression levels of CD40, CD80, CD86 and MHC II were evaluated in unlabeled, SPIO-loaded and PMA-activated B cells via flow cytometry, Fig. 1D.
Regulation (evaluated) of MHC II in B cells
5) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871797 Disease Relevance 0.09 Pain Relevance 0.13
Without MPTP administration, H2/Mg water had no effect on the number of TH-positive cells (195±8; non-H2/Mg water, 194±4; H2/Mg water, Figure 3A, 3C).
Neg (no) Regulation (effect) of H2 associated with parkinson's disease
6) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 0.83 Pain Relevance 0
Not only do innate immune cells down-regulate MHC II, but decreased numbers of Langerhans cells (LCs; the DCs of the skin) have been observed consistently in both elderly humans and old mice.
Regulation (regulate) of MHC II in DCs
7) Confidence 0.04 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2615427 Disease Relevance 0.05 Pain Relevance 0.04
It also has a partial, weak agonist effect on H1 and H2 receptors [61, 162].
Spec (partial) Regulation (effect) of H2 associated with agonist
8) Confidence 0.02 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2866460 Disease Relevance 0.54 Pain Relevance 0.09

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