INT257934

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.00
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HLA-DQA2) Golgi apparatus (HLA-DQA2) endoplasmic reticulum (HLA-DQA2)
plasma membrane (HLA-DQA2)
Anatomy Link Frequency
macrophages 2
monocyte 2
DCs 2
T lymphocytes 2
HLA-DQA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 53 99.90 Very High Very High Very High
Inflammation 97 99.70 Very High Very High Very High
Inflammatory response 39 98.36 Very High Very High Very High
Multiple sclerosis 14 78.64 Quite High
Central nervous system 22 43.64 Quite Low
Pain 3 22.88 Low Low
Demyelination 2 18.76 Low Low
Spinal cord 2 18.00 Low Low
cINOD 18 5.00 Very Low Very Low Very Low
addiction 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 142 99.70 Very High Very High Very High
Chorioamnionitis 32 93.52 High High
Paresis 6 90.52 High High
Alzheimer's Dementia 10 89.60 High High
Pre-term Labor 70 88.40 High High
Adhesions 6 86.68 High High
Multiple Sclerosis 50 78.64 Quite High
Recurrence 1 71.32 Quite High
Stroke 5 66.96 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 93 61.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
That is, activated macrophages from aged humans and mice produce higher amounts of the proinflammatory paracrine molecule prostaglandin E2 than younger individuals, which inhibits surface expression of MHC class II [65].
Negative_regulation (inhibits) of Gene_expression (expression) of MHC class II in macrophages
1) Confidence 0.04 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2615427 Disease Relevance 0.36 Pain Relevance 0.14
Studies have indicated that this diminished MHC class II expression over the life span is typical in both humans and mice [64,65].
Negative_regulation (diminished) of Gene_expression (expression) of MHC class II
2) Confidence 0.04 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2615427 Disease Relevance 0.11 Pain Relevance 0.04
Finally, the fourth mechanism is the modulation by statins of surface molecule expression and protein secretion; statins inhibit MHC class-II molecule expression on antigen presenting cells and endothelial cells [13], and CCR5 expression on T lymphocytes [18], while increases the secretion of RANTES and other cytokines [18].
Negative_regulation (inhibit) of Gene_expression (expression) of MHC class-II in T lymphocytes associated with cytokine
3) Confidence 0.04 Published 2009 Journal Trials Section Body Doc Link PMC2705367 Disease Relevance 0.37 Pain Relevance 0.12
There was a significant reduction of MHC Class II expression, as indicated by median fluorescence intensity (MFI), in those women who were positive for the bacterial ribosomal 16S gene by broad-range 16S rDNA endpoint PCR (p?
Negative_regulation (reduction) of Gene_expression (expression) of MHC Class II
4) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2785424 Disease Relevance 0.80 Pain Relevance 0.03
We and others have shown evidence of a maternal systemic inflammatory response in association with preterm labour with increased pro-inflammatory cytokines and decreased monocyte MHC Class II expression in maternal blood [26], [40]–[43].
Negative_regulation (decreased) of Gene_expression (expression) of MHC Class II in monocyte associated with inflammatory response, inflammation and cytokine
5) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2785424 Disease Relevance 0.97 Pain Relevance 0.22
and cytotoxicity [21]–[23]. 1,25(OH)2D3 negatively regulates the differentiation, maturation, and immunostimulatory capacity of DCs by decreasing the expression of MHC class II, CD40, CD80, and CD86 [24]–[26].
Negative_regulation (decreasing) of Gene_expression (expression) of MHC class II in DCs
6) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.39 Pain Relevance 0.13

General Comments

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