INT257948

Context Info Confidence 0.05 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.70

cytosol (CUBN) endosome (CUBN) small molecule metabolic process (CUBN) Golgi apparatus (CUBN) endoplasmic reticulum (CUBN) plasma membrane (CUBN)

CUBN (Homo sapiens)

Pain Link Frequency Relevance Heat Dopamine 108 100.00 agonist 14 85.64 Gabapentin 10 79.72 gABA 8 74.84 addiction 16 68.52 Nucleus accumbens 15 63.68 cocaine 12 63.16 depression 3 42.24 Neuropathic pain 1 27.68 alcohol 11 5.00

Disease Link Frequency Relevance Heat Syndrome 22 50.00 Depression 4 42.24 Anxiety Disorder 5 40.64 Fatigue 2 38.08 Cocaine Dependence 1 31.32 Neuropathic Pain 1 27.68 Convulsion 1 26.48 Recurrence 5 18.88 Stress 6 17.52 Adverse Drug Reaction 1 14.48

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Although DA release (and/or DA receptor binding) could in theory be potentiated by the above proposed ingredients (summarized in table 1) for dopaminergic activation, no one to date has actually shown this important potential and is the subject of future intensive investigation.

DA receptor Binding (binding) of associated with dopamine

1) Confidence 0.05 Published 2008 Journal Theor Biol Med Model Section Body Doc Link PMC2615745 Disease Relevance 0 Pain Relevance 0.70

General Comments

This test has worked.