INT257950

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Context Info
Confidence 0.08
First Reported 2002
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.27
Pain Relevance 2.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NLRP1) nucleus (NLRP1) intracellular (NLRP1)
enzyme binding (NLRP1) cytoplasm (NLRP1)
Anatomy Link Frequency
DA neurons 2
NLRP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 135 100.00 Very High Very High Very High
Nucleus accumbens 32 100.00 Very High Very High Very High
agonist 14 100.00 Very High Very High Very High
Glutamate 7 99.08 Very High Very High Very High
Ventral tegmentum 21 97.72 Very High Very High Very High
addiction 73 87.88 High High
withdrawal 25 86.80 High High
Substantia nigra 6 85.40 High High
opioid receptor 3 83.84 Quite High
noradrenaline 11 81.20 Quite High
Disease Link Frequency Relevance Heat
Drug Dependence 34 87.88 High High
Opiate Addiction 28 71.76 Quite High
Syndrome 22 50.00 Quite Low
Pain 3 35.04 Quite Low
Substance Withdrawal Syndrome 8 32.16 Quite Low
Recurrence 21 28.16 Quite Low
Obesity 31 22.64 Low Low
Weight Loss 4 12.88 Low Low
Stress 20 5.24 Low Low
Attention Deficit Hyperactivity Disorder 29 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our solution is to stimulate DA release at the NAc naturally, not via powerful DA agonists that could ultimately lead to DA down-regulation.
Neg (not) Regulation (regulation) of Localization (release) of NAc associated with nucleus accumbens, dopamine and agonist
1) Confidence 0.08 Published 2008 Journal Theor Biol Med Model Section Body Doc Link PMC2615745 Disease Relevance 0 Pain Relevance 0.87
Why then did the NAc BOLD response of the two groups not differ during reward delivery?
Neg (not) Regulation (differ) of Localization (response) of NAc associated with nucleus accumbens
2) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943904 Disease Relevance 0 Pain Relevance 0.38
In this second variant of the changed set point model, this resting level is the result of two factors that influence the amount of resting DA release in the NAc: cortical excitatory (glutamate) neurons that drive the VTA DA neurons to release DA, and autoreceptors (“brakes”) that shut down further release when DA concentrations become excessive.
Regulation (influence) of Localization (release) of NAc in DA neurons associated with ventral tegmentum, nucleus accumbens, glutamate and dopamine
3) Confidence 0.04 Published 2002 Journal Sci Pract Perspect Section Body Doc Link PMC2851054 Disease Relevance 0.27 Pain Relevance 1.36

General Comments

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