INT25796

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Context Info
Confidence 0.26
First Reported 1989
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 6
Total Number 8
Disease Relevance 2.77
Pain Relevance 4.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Adarb1) mRNA processing (Adarb1) nucleolus (Adarb1)
RNA binding (Adarb1) nucleus (Adarb1) intracellular (Adarb1)
Anatomy Link Frequency
spinal cord 4
brain 4
neuronal 2
spines 2
peroneal nerves 2
Adarb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 16 100.00 Very High Very High Very High
antagonist 11 100.00 Very High Very High Very High
Trk A 9 100.00 Very High Very High Very High
Spinal cord 8 100.00 Very High Very High Very High
opioid receptor 6 100.00 Very High Very High Very High
ischemia 6 100.00 Very High Very High Very High
mu opioid receptor 3 100.00 Very High Very High Very High
opiate 2 100.00 Very High Very High Very High
Glutamate receptor 2 100.00 Very High Very High Very High
Eae 4 98.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Spinal Cord Ischemia 3 100.00 Very High Very High Very High
Nicotine Addiction 3 99.78 Very High Very High Very High
Nociception 1 99.38 Very High Very High Very High
Injury 11 99.04 Very High Very High Very High
Neuropathic Pain 9 96.08 Very High Very High Very High
Cv Unclassified Under Development 3 94.56 High High
Gliosis 2 78.56 Quite High
Tooth Injuries 2 75.00 Quite High
Diabetes Mellitus 2 71.20 Quite High
Teratoma 2 71.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study examined the effects of spinal cord ischemia on the expression of mu-opioid receptors in rat dorsal spinal cord and the effects of intrathecal (i.t.) morphine on the acute mechanical allodynia that developed after spinal ischemia.
Spec (examined) Regulation (effects) of Gene_expression (expression) of receptors in spinal cord associated with allodynia, ischemia, mu opioid receptor, morphine, intrathecal and spinal cord
1) Confidence 0.26 Published 1999 Journal Neuroreport Section Abstract Doc Link 10094139 Disease Relevance 0.57 Pain Relevance 1.15
Cultures of aggregating guinea pig cerebellar cells were used to further study the factors regulating the expression of the three opioid receptors in this brain region.
Regulation (regulating) of Gene_expression (expression) of receptors in brain associated with opioid receptor
2) Confidence 0.18 Published 1989 Journal Dev. Neurosci. Section Abstract Doc Link 2553387 Disease Relevance 0 Pain Relevance 0.28
Paradoxical and subtype-specific effects of opiate antagonists on the expression of opioid receptors in rat brain cultures.
Regulation (effects) of Gene_expression (expression) of receptors in brain associated with antagonist, opioid receptor and opiate
3) Confidence 0.12 Published 1989 Journal J. Neurosci. Res. Section Title Doc Link 2540341 Disease Relevance 0 Pain Relevance 0.54
This study was designed to investigate whether naltrexone, an opioid antagonist that has been evaluated clinically as a co-adjuvant in smoking cessation programs, affects function and expression of neuronal nicotinic receptors (nAChRs).
Spec (whether) Regulation (affects) of Gene_expression (expression) of receptors in neuronal associated with nicotine addiction, antagonist and opioid
4) Confidence 0.08 Published 2000 Journal Neuropharmacology Section Abstract Doc Link 11044744 Disease Relevance 0.17 Pain Relevance 0.30
If NGF induces wound repair and/or nociceptive responses in tooth pulp, then changes in expression of NGF receptors (trk A receptors) in response to dentin injury would be expected.
Regulation (changes) of Gene_expression (expression) of receptors in dentin associated with nociception, nerve growth factor, trk a and injury
5) Confidence 0.04 Published 2000 Journal J Endod Section Abstract Doc Link 11194379 Disease Relevance 0.69 Pain Relevance 0.57
Spinal protein levels of these receptors were not changed by diabetes, while KOR levels in the sciatic and peroneal nerves were significantly increased.
Neg (not) Regulation (changed) of Gene_expression (levels) of receptors in peroneal nerves
6) Confidence 0.02 Published 2006 Journal Diabetologia Section Body Doc Link 16924480 Disease Relevance 0.07 Pain Relevance 0
Substantial alterations in neurotrophin receptors expression were observed in the spinal cord of CCI and NGF-treated animals.
Regulation (alterations) of Gene_expression (expression) of receptors in spinal cord associated with nerve growth factor, eae and spinal cord
7) Confidence 0.01 Published 2010 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 19585233 Disease Relevance 0.88 Pain Relevance 1.15
In contrast, patients' antibodies did not alter the localization or expression of other glutamate receptors or synaptic proteins, number of synapses, dendritic spines, dendritic complexity, or cell survival.
Neg (not) Regulation (alter) of Gene_expression (expression) of receptors in spines associated with glutamate receptor
8) Confidence 0.01 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3002330 Disease Relevance 0.40 Pain Relevance 0.32

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