INT257976

Context Info Confidence 0.00 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.31 Pain Relevance 0.11

plasma membrane (EGFR, PTGER2, RASGRP1) endoplasmic reticulum (EGFR, RASGRP1) Golgi apparatus (EGFR, RASGRP1) signal transducer activity (EGFR, PTGER2) cytoplasm (EGFR, RASGRP1) signal transduction (EGFR, RASGRP1)

EGFR (Homo sapiens) PTGER2 (Homo sapiens) RASGRP1 (Homo sapiens)

Pain Link Frequency Relevance Heat agonist 26 81.56 antagonist 7 68.80 withdrawal 7 12.80 cINOD 7 5.00 Potency 4 5.00 aspirin 1 5.00 COX-2 inhibitor 1 5.00 Inflammation 1 5.00 Pain 1 5.00 addiction 1 5.00

Disease Link Frequency Relevance Heat Colon Cancer 64 99.84 Apoptosis 17 5.00 Bordatella Infection 4 5.00 INFLAMMATION 4 5.00 Cancer 3 5.00 Stress 2 5.00 Pain 1 5.00 Adenocarcinoma 1 5.00 Malignant Neoplastic Disease 1 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

It has been proposed that transactivation of the EGFR mediates both Ras/Erk pathway activation and stimulation of cell growth by PGE2 in CRC cell lines [18,59,60].

Positive_regulation (transactivation) of EGFR Positive_regulation (mediates) of PGE2 Positive_regulation (activation) of Ras associated with colon cancer

1) Confidence 0.00 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0.31 Pain Relevance 0.11

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