INT257989

Context Info Confidence 0.01 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.61 Pain Relevance 0.21

plasma membrane (PTGER2, RASGRP1) cell differentiation (RASGRP1) Golgi apparatus (RASGRP1) endoplasmic reticulum (RASGRP1) cytoplasm (RASGRP1) signal transducer activity (PTGER2)

PTGER2 (Homo sapiens) RASGRP1 (Homo sapiens)

Pain Link Frequency Relevance Heat agonist 52 79.88 antagonist 14 67.12 withdrawal 14 22.16 cINOD 14 5.00 Potency 8 5.00 aspirin 2 5.00 COX-2 inhibitor 2 5.00 Inflammation 2 5.00 Pain 2 5.00 addiction 2 5.00

Disease Link Frequency Relevance Heat Colon Cancer 128 99.84 Apoptosis 34 5.00 Bordatella Infection 8 5.00 INFLAMMATION 8 5.00 Cancer 6 5.00 Stress 4 5.00 Pain 2 5.00 Adenocarcinoma 2 5.00 Malignant Neoplastic Disease 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

It has been proposed that transactivation of the EGFR mediates both Ras/Erk pathway activation and stimulation of cell growth by PGE2 in CRC cell lines [18,59,60].

PGE2 Positive_regulation (activation) of Ras associated with colon cancer

1) Confidence 0.01 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0.31 Pain Relevance 0.11

We have been unable to detect a significant stimulation of Ras or Erk activity by PGE2 in the cell lines studied here, even at longer time points of stimulation up to 3 h (data not shown).

PGE2 Positive_regulation (stimulation) of Ras

2) Confidence 0.01 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0.31 Pain Relevance 0.10

General Comments

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