INT2580

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Context Info
Confidence 0.58
First Reported 1979
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 1.34
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins1) extracellular region (Ins1) carbohydrate metabolic process (Ins1)
cytoplasm (Ins1)
Anatomy Link Frequency
plasma 4
hepatocytes 4
Ins1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
lidocaine 4 99.72 Very High Very High Very High
metalloproteinase 3 96.60 Very High Very High Very High
Bile 8 90.88 High High
Endogenous opioid 1 89.36 High High
opioid receptor 1 85.56 High High
narcan 1 83.60 Quite High
anesthesia 2 78.68 Quite High
alcohol 3 76.60 Quite High
Enkephalin 1 25.00 Low Low
Bioavailability 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 12 99.72 Very High Very High Very High
Hyperinsulinism 2 84.52 Quite High
Injury 4 75.00 Quite High
Wound Healing 1 61.20 Quite High
Adhesions 4 14.56 Low Low
Diabetes Mellitus 8 5.00 Very Low Very Low Very Low
Toxicity 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lectins and antimicrotubular agents, which are known to affect the mobility of plasma membrane proteins or of intracytoplasmic vesicles, selectively inhibited insulin degradation by hepatocytes to varying degrees, whereas agents which inhibit the function of microfilaments had no effect.
Negative_regulation (inhibited) of Protein_catabolism (degradation) of insulin in plasma
1) Confidence 0.58 Published 1979 Journal Can. J. Biochem. Section Abstract Doc Link 476501 Disease Relevance 0.22 Pain Relevance 0.07
Various lysosomotropic agents, including chloroquine, ammonium chloride, and the topical anesthetics, lidocaine and procaine inhibited insulin degradation by H4 hepatoma cells but had little effect on the binding of the hormone.
Negative_regulation (inhibited) of Protein_catabolism (degradation) of insulin associated with hepatocellular cancer and lidocaine
2) Confidence 0.58 Published 1979 Journal Can. J. Biochem. Section Abstract Doc Link 476501 Disease Relevance 0.27 Pain Relevance 0.10
Similarly, tosyl-L-lysyl chloromethyl ketone selectively inhibited the degradation of 125I-labelled insulin by isolated hepatocytes, as did the sulfhydryl reagents, p-hydroxy- and p-chloromercuriphenyl sulfonic acid.
Negative_regulation (inhibited) of Protein_catabolism (degradation) of insulin in hepatocytes
3) Confidence 0.58 Published 1979 Journal Can. J. Biochem. Section Abstract Doc Link 476501 Disease Relevance 0.26 Pain Relevance 0.09
Inhibitors of energy production, including sodium fluoride, sodium azide, and dinitrophenol, also selectively inhibited the degradation of insulin by hepatocytes, although cyanide had no effect under the conditions used.
Negative_regulation (inhibited) of Protein_catabolism (degradation) of insulin in hepatocytes
4) Confidence 0.58 Published 1979 Journal Can. J. Biochem. Section Abstract Doc Link 476501 Disease Relevance 0.24 Pain Relevance 0.08
Thus, the blood glucose-lowering action of racecadotril was related to insulin secretion, but not through the inhibition of plasma insulin degradation.
Negative_regulation (inhibition) of Protein_catabolism (degradation) of insulin in plasma
5) Confidence 0.57 Published 2010 Journal Horm. Metab. Res. Section Abstract Doc Link 20143290 Disease Relevance 0 Pain Relevance 0.17
Coinfusion with an excess of unlabeled insulin impaired the clearance and degradation of labeled insulin.
Negative_regulation (impaired) of Protein_catabolism (degradation) of insulin
6) Confidence 0.52 Published 1990 Journal Peptides Section Abstract Doc Link 2188232 Disease Relevance 0 Pain Relevance 0
Exogenous steroid administration caused a decrease in WF insulin-degrading activity.
Negative_regulation (decrease) of Protein_catabolism (degrading) of insulin
7) Confidence 0.31 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9357792 Disease Relevance 0.36 Pain Relevance 0.17
Encapsulation of insulin with the sugar chain portion of mucin and that of polyethylene glycol completely suppressed the degradation of insulin in the intestinal fluid, whereas uncoated liposomes suppressed it only partially.
Negative_regulation (suppressed) of Protein_catabolism (degradation) of insulin
8) Confidence 0.15 Published 2008 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC2792531 Disease Relevance 0 Pain Relevance 0.12
Carbopol polymers have been shown to inhibit luminal degradation of insulin, calcitonin, and insulin-like growth factor-I (IGF-I) by trypsin and chymotrypsin61.
Spec (like) Negative_regulation (inhibit) of Protein_catabolism (degradation) of insulin
9) Confidence 0.11 Published 2008 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC2792531 Disease Relevance 0 Pain Relevance 0

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