INT25800

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Context Info
Confidence 0.06
First Reported 1989
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.22
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ptprg)
Ptprg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 8 97.64 Very High Very High Very High
Potency 4 83.04 Quite High
nav1.8 1 75.00 Quite High
opioid receptor 2 57.24 Quite High
Serotonin 1 54.08 Quite High
tetrodotoxin 1 48.80 Quite Low
Disease Link Frequency Relevance Heat
Bordatella Infection 4 84.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While the effect of GTP(gammaS) was prevented by pretreatment with H7 (100 micro M), a non-selective PKA/PKC inhibitor, the fluoride-induced increase in Na(v)1.8 current was not sensitive to H7 (100 micro M), or to inclusion of deferoxamine (1 mM) in the intracellular solution.
Negative_regulation (prevented) of Negative_regulation (effect) of gammaS
1) Confidence 0.06 Published 2003 Journal Exp Brain Res Section Abstract Doc Link 12898089 Disease Relevance 0 Pain Relevance 0.10
GDP blocked the inhibitory effect of GTP gamma S (0.3 microM) in a concentration-dependent manner; the EC50 for GDP was 16 +/- 2.6 microM in the absence of morphine and 170 +/- 32 microM in the presence of morphine.
Negative_regulation (blocked) of Negative_regulation (effect) of GTP gamma S associated with morphine
2) Confidence 0.01 Published 1989 Journal Mol. Endocrinol. Section Abstract Doc Link 2540429 Disease Relevance 0.22 Pain Relevance 0.72

General Comments

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