INT258010

Context Info Confidence 0.69 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.51 Pain Relevance 0.06

signal transduction (Rassf1) plasma membrane (Rassf1) cytoskeleton (Rassf1) nucleus (Rassf1) cell cycle (Rassf1) cytoplasm (Rassf1)

Anatomy Link Frequency MCF-7 1 Rassf1 (Mus musculus)

Pain Link Frequency Relevance Heat local anesthetic 11 55.20 depression 3 44.20 Central nervous system 1 38.12 Bioavailability 9 30.24 Neurotransmitter 1 9.12 gABA 5 7.76 antagonist 37 5.00 Inflammation 11 5.00 agonist 9 5.00 Angina 7 5.00

Disease Link Frequency Relevance Heat Nasopharynx Cancer 1 99.64 Breast Cancer 17 95.32 Cancer 131 83.00 Renal Disease 4 58.12 Coma 1 44.60 Depression 3 44.20 Convulsion 1 43.24 Tremor 2 42.16 Akathisia 1 41.80 Heart Rate Under Development 18 35.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Procaine has also shown to inhibit growth and to reactivate the expression of RASSF1A mRNA in nasopharyngeal cancer cell lines [191], as well as to reactivate estrogen receptor-gene expression in MCF-7 breast cancer cells [192].

Transcription (expression) of RASSF1A in MCF-7 associated with nasopharynx cancer and breast cancer

1) Confidence 0.69 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 0.51 Pain Relevance 0.06

General Comments

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