INT258016

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Context Info
Confidence 0.15
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.24
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (AGTR1, EGFR) plasma membrane (AGTR1, EGFR) endosome (EGFR)
cell morphogenesis (EGFR) Golgi apparatus (EGFR) endoplasmic reticulum (EGFR)
AGTR1 (Homo sapiens)
EGFR (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 11 97.76 Very High Very High Very High
antagonist 37 84.36 Quite High
cytokine 2 44.80 Quite Low
chemokine 1 43.68 Quite Low
agonist 9 14.00 Low Low
local anesthetic 11 5.00 Very Low Very Low Very Low
Bioavailability 9 5.00 Very Low Very Low Very Low
Angina 7 5.00 Very Low Very Low Very Low
gABA 5 5.00 Very Low Very Low Very Low
Calcium channel 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 131 99.84 Very High Very High Very High
INFLAMMATION 15 97.76 Very High Very High Very High
Stomach Cancer 3 70.56 Quite High
Apoptosis 36 64.48 Quite High
Lung Cancer 8 56.20 Quite High
Carcinoma 2 50.16 Quite High
Pancreatic Cancer 2 47.84 Quite Low
Heart Rate Under Development 18 18.60 Low Low
Pressure Volume 2 Under Development 1 17.56 Low Low
Hypertension 9 17.04 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AT1R is able to transactivate EGFR in cancer cell lines, which leads to ERK, STAT3, and PKC activation [102-105].
AT1R Positive_regulation (transactivate) of EGFR associated with cancer
1) Confidence 0.15 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 1.24 Pain Relevance 0.13

General Comments

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