INT25802

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.11
First Reported 1982
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 2.66
Pain Relevance 5.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rtcd1) molecular_function (Rtcd1) ligase activity (Rtcd1)
Anatomy Link Frequency
brain 2
Rtcd1 (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 16 100.00 Very High Very High Very High
opiate 7 99.92 Very High Very High Very High
agonist 20 99.40 Very High Very High Very High
Neurotransmitter 1 99.32 Very High Very High Very High
Potency 4 99.10 Very High Very High Very High
MU agonist 1 98.50 Very High Very High Very High
Morphine 15 98.06 Very High Very High Very High
dorsal root ganglion 1 95.44 Very High Very High Very High
withdrawal 1 94.52 High High
Enkephalin 5 92.48 High High
Disease Link Frequency Relevance Heat
Bordatella Infection 8 96.80 Very High Very High Very High
Neuroblastoma 3 95.20 Very High Very High Very High
Opiate Addiction 1 94.88 High High
Glioma 2 94.56 High High
Ganglion Cysts 4 94.48 High High
Pulmonary Disease 3 92.72 High High
Targeted Disruption 1 90.48 High High
INFLAMMATION 18 89.44 High High
Disease 8 88.40 High High
Injury 12 86.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As expected, stimulation of mu, delta, and D2 receptors on brain tissue of wild-type animals induced a dose-dependent decrease in adenylate cyclase activity, whereas a striking mirror effect was observed in mutants.
Positive_regulation (induced) of Negative_regulation (decrease) of cyclase in brain
1) Confidence 0.11 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11880531 Disease Relevance 0.57 Pain Relevance 1.28
PTX is known to interfere with the guanine nucleotide protein Gi that is required for opioid, alpha 2-adrenergic and muscarinic receptor-mediated inhibition of adenylate cyclase in various cells.
Positive_regulation (required) of Negative_regulation (inhibition) of cyclase associated with opioid
2) Confidence 0.05 Published 1987 Journal Brain Res. Section Abstract Doc Link 3545389 Disease Relevance 0.50 Pain Relevance 1.19
Ni thus appears to mediate guanylate cyclase activation as well as adenylate cyclase inhibition initiated via the same receptors.
Spec (appears) Positive_regulation (mediate) of Negative_regulation (inhibition) of cyclase
3) Confidence 0.03 Published 1985 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 2986551 Disease Relevance 0.38 Pain Relevance 0.31
Treatment of these cell lines with morphine and other mu agonists inhibited forskolin-induced cAMP accumulation, demonstrating a functional coupling of mMOR to the inhibition of adenylate cyclase.
Positive_regulation (coupling) of Negative_regulation (inhibition) of cyclase associated with mu agonist and morphine
4) Confidence 0.02 Published 1995 Journal J. Biol. Chem. Section Abstract Doc Link 7797593 Disease Relevance 0 Pain Relevance 0.84
However, the relative potency of GDP in blocking the GTP gamma S-mediated inhibition of cyclase was increased: the EC50 values of GDP were 11 +/- 4 and 0.81 +/- 0.2 microM in untreated and pertussis toxin-treated membranes, respectively.
Positive_regulation (increased) of Negative_regulation (inhibition) of cyclase associated with bordatella infection and potency
5) Confidence 0.01 Published 1989 Journal Mol. Endocrinol. Section Abstract Doc Link 2540429 Disease Relevance 0.34 Pain Relevance 0.77
Na+ has been implicated as a requirement for the inhibition of adenylate cyclase by hormones and neurotransmitters.
Positive_regulation (requirement) of Negative_regulation (inhibition) of cyclase associated with neurotransmitter
6) Confidence 0.01 Published 1982 Journal J Cyclic Nucleotide Res Section Abstract Doc Link 6757290 Disease Relevance 0.09 Pain Relevance 0.09
Signaling requires pertussistoxin sensitive Gi protein, leading to a reduction in adenylate cyclase activity.
Positive_regulation (leading) of Negative_regulation (reduction) of cyclase
7) Confidence 0.01 Published 2008 Journal Crit Care Section Body Doc Link PMC2592730 Disease Relevance 0.59 Pain Relevance 0.36
An explanation for the dual requirement for Na+ and GTP in inhibitory regulation of adenylate cyclase.
Positive_regulation (requirement) of Negative_regulation (regulation) of cyclase
8) Confidence 0.00 Published 1982 Journal J. Biol. Chem. Section Title Doc Link 6128341 Disease Relevance 0.19 Pain Relevance 0.72

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox