INT258021

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Context Info
Confidence 0.11
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.84
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CDK2, CDKN1A) cytoplasm (CDK2, CDKN1A) cytosol (CDK2, CDKN1A)
nucleus (CDK2, CDKN1A) cell cycle (CDK2, CDKN1A) kinase activity (CDK2, CDKN1A)
CDK2 (Homo sapiens)
CDKN1A (Homo sapiens)
Pain Link Frequency Relevance Heat
corticosteroid 1 72.96 Quite High
antagonist 37 64.64 Quite High
Bile 2 11.84 Low Low
dexamethasone 2 5.16 Low Low
Inflammation 11 5.00 Very Low Very Low Very Low
local anesthetic 11 5.00 Very Low Very Low Very Low
Bioavailability 9 5.00 Very Low Very Low Very Low
agonist 9 5.00 Very Low Very Low Very Low
Angina 7 5.00 Very Low Very Low Very Low
gABA 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ovarian Cancer 6 97.52 Very High Very High Very High
Prostate Cancer 11 89.16 High High
Apoptosis 36 88.16 High High
Adenocarcinoma 2 85.84 High High
Lung Cancer 8 83.52 Quite High
Breast Cancer 17 42.68 Quite Low
Leukemia 3 40.08 Quite Low
Death 8 39.24 Quite Low
Hepatocellular Cancer 3 37.44 Quite Low
Stomach Cancer 3 25.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A cytostatic effect of mifepristone has also been shown in ovarian cancer cells by blocking DNA synthesis and cell cycle arrest at the G1-S transition via reduction of cdk2 activity, likely due to increased cdk2 association with cdk inhibitors p21 and -27 and reduced nuclear cdk2/cyclin E complex availability [383].
Positive_regulation (increased) of cdk2 Spec (likely) Binding (association) of p21 associated with ovarian cancer
1) Confidence 0.11 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 0.84 Pain Relevance 0.07

General Comments

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