INT258045

Context Info Confidence 0.36 First Reported 2008 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.78 Pain Relevance 0.03

mitochondrion (BCL2) cell morphogenesis (BCL2) endoplasmic reticulum (BCL2) intracellular (BCL2) cytoplasm (BCL2) cytosol (BCL2)

BCL2 (Homo sapiens)

Pain Link Frequency Relevance Heat corticosteroid 1 50.24 antagonist 37 41.92 Bile 2 24.36 dexamethasone 2 17.68 Inflammation 11 5.00 local anesthetic 11 5.00 Bioavailability 9 5.00 agonist 9 5.00 Angina 7 5.00 gABA 5 5.00

Disease Link Frequency Relevance Heat Apoptosis 96 100.00 Prostate Cancer 11 100.00 Adenocarcinoma 2 98.36 Lung Cancer 10 96.04 Ovarian Cancer 7 92.32 Repression 4 72.64 Neuroblastoma 3 62.84 Cancer 154 55.84 Breast Cancer 18 55.20 Death 14 51.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In contrast, no significant changes in BCL2 protein levels were detected at 0, 24, or 72 h in the empty vector-transfected cells with or without miR-34a inhibition (Figure 9B, bottom panel).

Neg (no) Positive_regulation (changes) of Neg (no) Regulation (changes) of BCL2

1) Confidence 0.36 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0.66 Pain Relevance 0

Mifepristone also induced apoptosis in human prostate cancer LNCaP cells by regulating Bcl-2 gene and TGF?

Positive_regulation (induced) of Regulation (regulating) of Bcl-2 gene associated with prostate cancer and apoptosis

2) Confidence 0.10 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 1.12 Pain Relevance 0.03

General Comments

This test has worked.