INT258048

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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.81
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TBK1) plasma membrane (TBK1) cytoplasm (TBK1)
Anatomy Link Frequency
endothelial cells 1
TBK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 9 99.60 Very High Very High Very High
Catechol-O-methyltransferase 111 98.46 Very High Very High Very High
cytokine 19 98.40 Very High Very High Very High
Inflammation 101 98.00 Very High Very High Very High
cINOD 36 87.92 High High
metalloproteinase 3 84.32 Quite High
IPN 8 71.36 Quite High
Pain 46 63.60 Quite High
Bile 4 52.16 Quite High
dexamethasone 4 45.48 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 72 99.92 Very High Very High Very High
INFLAMMATION 115 98.00 Very High Very High Very High
Arthropathy 2 87.92 High High
Breast Cancer 34 83.00 Quite High
Death 17 79.56 Quite High
Injury 15 71.60 Quite High
Inflammatory Pain 8 71.36 Quite High
Lung Cancer 16 66.96 Quite High
Stomach Cancer 6 66.12 Quite High
Prostate Cancer 22 65.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Aspirin is now believed to target both the NF-kB and COX pathways.
Regulation (target) of NF-kB associated with aspirin
1) Confidence 0.05 Published 2010 Journal Surgical Neurology International Section Body Doc Link PMC3011108 Disease Relevance 0.90 Pain Relevance 0.72
Apoptosis induction has been reported by means of regulation of NF-kB [390], one of the early response transcription factors that play an important role in the regulation of genes involved in apoptosis.
Regulation (regulation) of NF-kB associated with apoptosis
2) Confidence 0.04 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 1.27 Pain Relevance 0.03
NF-kB up-regulation in endothelial cells stimulates apoptosis by 75%.
Regulation (regulation) of NF-kB in endothelial cells associated with apoptosis
3) Confidence 0.02 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 1.39 Pain Relevance 0
This oscillatory rather than linear pattern of MB-COMT mRNA expression is in agreement with previously reported characteristics of NF-kB-mediated gene regulation and has been associated with autoregulation of NF-?
Regulation (regulation) of NF-kB-mediated associated with catechol-o-methyltransferase
4) Confidence 0.01 Published 2009 Journal Mol Pain Section Body Doc Link PMC2662804 Disease Relevance 0.25 Pain Relevance 0.69

General Comments

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