INT258051

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.86
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (ABAT)
Anatomy Link Frequency
brain 8
ABAT (Homo sapiens)
Pain Link Frequency Relevance Heat
gABA 22 100.00 Very High Very High Very High
Neurotransmitter 6 99.38 Very High Very High Very High
Bioavailability 20 88.16 High High
anticonvulsant 4 74.00 Quite High
depression 24 66.80 Quite High
Migraine 8 51.60 Quite High
headache 12 50.88 Quite High
local anesthetic 22 7.04 Low Low
antagonist 74 5.00 Very Low Very Low Very Low
Inflammation 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Manic Depressive Disorder 22 96.36 Very High Very High Very High
Epilepsy 20 95.16 Very High Very High Very High
Convulsion 14 91.76 High High
Depression 20 66.80 Quite High
Absence Epilepsy 4 65.44 Quite High
Partial Seizures 2 60.56 Quite High
Juvenile Myoclonic Epilepsy 2 58.72 Quite High
Breast Cancer 44 57.88 Quite High
Nasopharynx Cancer 2 53.88 Quite High
Syndrome 26 52.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the human brain, valproic acid affects neurotransmitter GABA function by potentiating GABA inhibitory activity by several means, including inhibition of GABA degradation, increased GABA synthesis, and decreased GABA turnover.
Negative_regulation (inhibition) of Protein_catabolism (degradation) of GABA in brain associated with gaba and neurotransmitter
1) Confidence 0.04 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 0.40 Pain Relevance 0.34
In the human brain, valproic acid affects neurotransmitter GABA function by potentiating GABA inhibitory activity by several means, including inhibition of GABA degradation, increased GABA synthesis, and decreased GABA turnover.
Negative_regulation (inhibition) of Protein_catabolism (degradation) of GABA in brain associated with gaba and neurotransmitter
2) Confidence 0.04 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 0.39 Pain Relevance 0.34
In the human brain, VPA alters the activity of the neurotransmitter Gamma Amino Butyrate (GABA) by potentialising the inhibitory activity of GABA through several mechanisms, including inhibition of GABA degradation, inhibition of GABA Transaminobutyratre (ABAT), increased GABA synthesis, and decreased turnover [5].
Negative_regulation (inhibition) of Protein_catabolism (degradation) of GABA in brain associated with gaba and neurotransmitter
3) Confidence 0.02 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2926634 Disease Relevance 0.57 Pain Relevance 0.47
In the human brain, VPA alters the activity of the neurotransmitter Gamma Amino Butyrate (GABA) by potentialising the inhibitory activity of GABA through several mechanisms, including inhibition of GABA degradation, inhibition of GABA Transaminobutyratre (ABAT), increased GABA synthesis, and decreased turnover [5].
Negative_regulation (inhibition) of Protein_catabolism (degradation) of GABA in brain associated with gaba and neurotransmitter
4) Confidence 0.02 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2926634 Disease Relevance 0.50 Pain Relevance 0.36

General Comments

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