INT258053

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.27
First Reported 2006
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 7.37
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (HDAC9) transcription factor binding (HDAC9) cytoplasm (HDAC9)
Anatomy Link Frequency
blood 2
brain 2
HDAC9 (Homo sapiens)
Pain Link Frequency Relevance Heat
bDMF 26 99.96 Very High Very High Very High
Inflammation 61 97.32 Very High Very High Very High
corticosteroid 14 96.36 Very High Very High Very High
adenocard 4 94.12 High High
fibrosis 19 92.20 High High
Potency 4 85.68 High High
depression 76 85.28 High High
imagery 6 76.24 Quite High
antidepressant 42 71.80 Quite High
Hippocampus 15 70.68 Quite High
Disease Link Frequency Relevance Heat
Death 33 100.00 Very High Very High Very High
Cancer 247 99.64 Very High Very High Very High
Stress 33 99.44 Very High Very High Very High
Apoptosis 127 98.76 Very High Very High Very High
Pulmonary Disease 107 98.36 Very High Very High Very High
Synovial Sarcoma 70 98.16 Very High Very High Very High
INFLAMMATION 63 97.32 Very High Very High Very High
Pancreatic Cancer 26 96.72 Very High Very High Very High
Solid Tumor 5 94.12 High High
Malignant Neoplastic Disease 18 93.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a recently published study by our research group, we demonstrated that HDAC Class I and II inhibitors such as TSA can induce death of tumor cell lines via apoptosis [63].
Positive_regulation (induce) of Negative_regulation (inhibitors) of HDAC associated with cancer, apoptosis and death
1) Confidence 0.27 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2964042 Disease Relevance 1.28 Pain Relevance 0
Currently, there are several clinical phase I and II studies reported that show that valproic acid induces histone hyperacetylation and HDAC activity inhibition in both tumors and the peripheral blood of patients, and when associated with chemotherapy exhibits encouraging antitumor responses in a range of solid tumors and malignant hematological diseases.
Positive_regulation (induces) of Negative_regulation (inhibition) of HDAC in blood associated with hematological disease, malignant neoplastic disease, cancer and solid tumor
2) Confidence 0.20 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 0.85 Pain Relevance 0.06
Previous studies have shown that HDAC inhibitors not only induce cell death but also activate the survival pathway NF-?
Positive_regulation (induce) of Negative_regulation (inhibitors) of HDAC associated with death
3) Confidence 0.19 Published 2009 Journal Sarcoma Section Abstract Doc Link PMC2659882 Disease Relevance 0.70 Pain Relevance 0
Previous studies have shown that HDAC inhibitors not only induce cell death but also activate the survival pathway NF-?
Positive_regulation (activate) of Negative_regulation (inhibitors) of HDAC associated with death
4) Confidence 0.19 Published 2009 Journal Sarcoma Section Abstract Doc Link PMC2659882 Disease Relevance 0.70 Pain Relevance 0
HDAC inhibitors also play a role as microtubule-associated deacetylases and cause acetylation of lysine40 of ?
Positive_regulation (cause) of Negative_regulation (inhibitors) of HDAC
5) Confidence 0.13 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2994814 Disease Relevance 0.78 Pain Relevance 0.16
On the other hand, recent evidence suggests that HDAC inhibitors also enhance the acetylation of non-histone proteins, such as p53, c-Jun, and ?
Positive_regulation (enhance) of Negative_regulation (inhibitors) of HDAC
6) Confidence 0.13 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2994814 Disease Relevance 0.97 Pain Relevance 0.04
VPA induced significant histone deacetylase (HDAC) inhibition in most of the cell lines, but the degree of inhibition was highly cell type-specific.
Positive_regulation (induced) of Negative_regulation (inhibition) of HDAC
7) Confidence 0.12 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2918577 Disease Relevance 0.25 Pain Relevance 0
Another study showed that HDAC inhibitors such as VPA, SB, and TSA increase BDNF expression in the brain [51].
Positive_regulation (increase) of Negative_regulation (inhibitors) of HDAC in brain associated with bdmf
8) Confidence 0.07 Published 2010 Journal Mol Brain Section Body Doc Link PMC2848031 Disease Relevance 0.89 Pain Relevance 0.49
The latter mechanism may be very useful to restore HDAC activity impaired by oxidative stress, thus resensitizing COPD patients to the anti-inflammatory effects of corticosteroids.
Positive_regulation (restore) of Negative_regulation (impaired) of HDAC associated with stress, corticosteroid, pulmonary disease and inflammation
9) Confidence 0.06 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707155 Disease Relevance 0.94 Pain Relevance 0.48

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox