INT258059

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.79
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GSR) mitochondrion (GSR) small molecule metabolic process (GSR)
oxidoreductase activity (GSR) cytoplasm (GSR)
GSR (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 48 98.56 Very High Very High Very High
gABA 5 21.16 Low Low
Neurotransmitter 1 14.76 Low Low
antagonist 37 5.00 Very Low Very Low Very Low
Inflammation 11 5.00 Very Low Very Low Very Low
local anesthetic 11 5.00 Very Low Very Low Very Low
Bioavailability 9 5.00 Very Low Very Low Very Low
agonist 9 5.00 Very Low Very Low Very Low
Angina 7 5.00 Very Low Very Low Very Low
depression 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 1 100.00 Very High Very High Very High
Diabetes Mellitus 46 99.84 Very High Very High Very High
Affective Disorder 24 98.40 Very High Very High Very High
Cataract 45 95.88 Very High Very High Very High
Congenital Anomalies 3 81.48 Quite High
Injury 23 79.00 Quite High
Ocular Hypertension 1 77.84 Quite High
Hepatotoxicity 2 75.88 Quite High
Liver Failure 2 74.24 Quite High
Post-traumatic Stress Disorder 3 70.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The exaggerated cortisol response to the dex/CRH test in mood disorder patients who do not report high levels of childhood emotional neglect suggests reduced GR mediated negative feedback in these patients.
Negative_regulation (reduced) of Positive_regulation (mediated) of GR associated with affective disorder
1) Confidence 0.41 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656301 Disease Relevance 0.35 Pain Relevance 0
The loss of enzyme activity, such as GR, induced by diabetes was also alleviated by aspirin [15,48,49].
Negative_regulation (loss) of Positive_regulation (induced) of GR associated with aspirin and diabetes mellitus
2) Confidence 0.11 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2773744 Disease Relevance 0.90 Pain Relevance 0.33
The finding that VPA was an effective inhibitor of HDACs arose from observations that valproic acid was able to relieve transcriptional repression of a peroxisomal proliferation and activation of a glucocorticoid receptor (GR)-PPAR?
Negative_regulation (relieve) of Positive_regulation (activation) of GR associated with repression
3) Confidence 0.10 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 0.54 Pain Relevance 0

General Comments

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